Rizzato G, Bertoli L, Merlini R, Tansini G, Scoccia S, Mantero O, Conti F
G Ital Cardiol. 1980;10(3):309-15.
Svanborg (1961) found normal pulmonary artery mean pressures in eleven patients with stage II sarcoidosis. By contrast Gluskowski et al. (1978) have shown few abnormally high values in the same condition. We have not found published haemodynamic data concerning stage O sarcoidosis. Thus we have performed right haemodynamic study (by Swan-Ganz catheters) on 19 patients with hystologically proven sarcoidosis (8 stage III, 6 stage II, 3 stage I and 2 stage 0). 13 of them underwent also haemodynamic study during exercise (1watt/Kg). Pulmonary artery hypertension (at rest or after exercise) was frequently found in stage III, and less frequently in stage II. In stage I pulmonary artery mean pressure was between 15 and 20 mmHg in three patients (out of three). In one case (out of two) in stage 0 (admitted to hospital owing to exertional dyspnoea) right heart catheterisation showed pulmonary hypertension during exercise in spite of normal pulmonary function tests (including spirometry, DLCO, pulmonary scintigrafic and X-ray pattern also using 3X magnification radiology).
斯凡伯格(1961年)发现,11例II期结节病患者的肺动脉平均压正常。相比之下,格鲁斯科夫斯基等人(1978年)表明,在相同情况下,只有少数异常高值。我们尚未找到关于0期结节病的血流动力学数据。因此,我们对19例经组织学证实为结节病的患者(8例III期、6例II期、3例I期和2例0期)进行了右心血流动力学研究(通过Swan-Ganz导管)。其中13例患者还在运动期间(1瓦/千克)进行了血流动力学研究。III期患者经常出现肺动脉高压(静息时或运动后),II期患者出现的频率较低。在I期,3例患者中有3例肺动脉平均压在15至20 mmHg之间。在0期的1例患者(2例中的1例)中(因劳力性呼吸困难入院),尽管肺功能测试(包括肺活量测定、一氧化碳弥散量、肺闪烁显像和X线胸片,也使用3倍放大的放射学检查)正常,但右心导管检查显示运动期间存在肺动脉高压。