[Comparative study in nuclear and cytoplasmic RNA species of mouse liver, Guelstein ascites hepatoma 22A and liver of tumor-bearing animals].

A comparative study on nuclear and cytoplasmic DNA-like RNA species from normal liver, malignant Guelstein hepatoma 22A and liver of tumor-bearing animals was carried out. The nuclear RNA's were found to be poorly and rapidly labelling, the latter comprising a lesser proportion in hepatoma as compared with a normal liver. The comparison of labelling rates of nuclear and cytoplasmic RNA species shows that the nucleus-to-cytoplasme RNA transport is accelerated in hepatoma. Besides, cytoplasmic DNA-like RNA's are more heterogeneous in hepatoma and liver of tumor-bearing animals than in normal liver cells.