动脉导管对氧气的发育反应。

The developmental response of the ductus arteriosus to oxygen.

作者信息

Clyman R I, Mauray F, Wong L, Heymann M A, Rudolph A M

出版信息

Biol Neonate. 1978;34(3-4):177-81. doi: 10.1159/000241124.

Abstract

We studied the isometric contractile effects of increased PO2 on isolated rings of lamb ductus arteriosus (from three different gestational age groups). When rings were stretched to initial lengths that result in a maximal contractile response for rings in that age group, the oxygen-induced contraction was 5.91 +/- 0.72 g/mm2 (+/-SEM, n = 18) in animals older than 135 days, 5.55 +/- 1.23 g/mm2 (n = 18) in animals between 111 and 130 days, and 3.85 +/- 0.75 g/mm2 (n = 19) in animals between 87 and 110 days. Only in the most immature vessels could a decrease in the tissue's response to oxygen be observed.

摘要

我们研究了PO2升高对分离的羊动脉导管环（来自三个不同胎龄组）的等长收缩效应。当将环拉伸至该年龄组中环产生最大收缩反应的初始长度时，135天以上动物的氧诱导收缩为5.91±0.72 g/mm2（±SEM，n = 18），111至130天动物为5.55±1.23 g/mm2（n = 18），87至110天动物为3.85±0.75 g/mm2（n = 19）。只有在最不成熟的血管中才能观察到组织对氧的反应降低。