在发育过程中，饱和脂肪酸是否存在血脑关系？

Is there a blood-brain relationship for saturated fatty acids during development?

作者信息

Bourre J M, Gozlan-Devillierre N, Daudu O, Baumann N

出版信息

Biol Neonate. 1978;34(3-4):182-6. doi: 10.1159/000241125.

DOI:10.1159/000241125

Abstract

Transport of subcutaneously injected [1-14C]-stearic acid through the blood-brain barrier is compared with endogenous biosynthesis (within the brain) during postnatal brain development in mice. The uptake is very important during glial cell multiplication and myelination; endogenous microsomal synthesis is most active during myelination, soluble de novo mechanism is prominent during cell multiplication (mitochondrial systems are not directly related to these events). A parallel is drawn between myelin fatty acids, microsomal synthesis and uptake from the blood.

摘要

在小鼠出生后脑发育过程中，将皮下注射的[1-14C]硬脂酸通过血脑屏障的转运与内源性生物合成（脑内）进行比较。在神经胶质细胞增殖和髓鞘形成过程中，摄取非常重要；内源性微粒体合成在髓鞘形成过程中最为活跃，可溶性从头合成机制在细胞增殖过程中占主导地位（线粒体系统与这些事件无直接关系）。文中对髓磷脂脂肪酸、微粒体合成和从血液中的摄取进行了比较。

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