Thibeault D W, Emmanouilides G C, Dodge M E
Biol Neonate. 1978;34(5-6):238-47. doi: 10.1159/000241135.
The effects of the in utero intravenous administration of hydrocortisone on postnatal lung function and pulmonary and systemic hemodynamics were studied in preterm fetal lambs and compared with those of non-treated animals of similar gestational ages. The results indicate that steroid-induced changes in lung pressure volume curves, although statistically significant, did not render the pretreated fetuses capable of surviving without ventilatory assistance. In addition, the ductus arteriosus in the steroid-treated lambs at 2 h of age was functionally closed or constricted regardless of gestational age. In contrast, in the untreated lambs the ductus arteriosus was widely patent and, especially in lambs of less than 120 days gestation, there was invariably a large left-to-right ductal shunt.
在早产胎儿羊羔中研究了宫内静脉注射氢化可的松对出生后肺功能、肺和全身血流动力学的影响，并与相似胎龄的未治疗动物进行了比较。结果表明，类固醇引起的肺压力-容积曲线变化虽然具有统计学意义，但并未使预处理的胎儿能够在无通气辅助的情况下存活。此外，无论胎龄如何，接受类固醇治疗的羊羔在2小时龄时动脉导管功能上已关闭或收缩。相比之下，未治疗的羊羔动脉导管广泛开放，尤其是在妊娠少于120天的羊羔中，总是存在大量的左向右导管分流。
