Barzilai D, Dickstein G, Kanter Y, Plavnick Y, Schramek A
J Clin Endocrinol Metab. 1980 May;50(5):853-6. doi: 10.1210/jcem-50-5-853.
A 15-yr-old girl was diagnosed as suffering from Cushing's disease. She was treated by bilateral adrenalectomy and autotransplantation of one third of each adrenal to the corresponding thigh. The adrenal that was embedded in the right satorius muscle started functioning after about 1 yr, as proven by significant differences in cortisol levels in both femoral veins (82.5 and 17.5 micrograms/100 ml). 19-[131I]Cholesterol scanning showed adrenal tissue in the right thigh, while no adrenal remnant was demonstrated. Eleven years after surgery, the patient is symptom free and does not require replacement therapy. We find that adrenal autotransplantation, which is a simple and nonrisky procedure, should be considered whenever bilateral adrenalectomy is chosen as a treatment for Cushing's disease.
一名15岁女孩被诊断患有库欣病。她接受了双侧肾上腺切除术，并将每侧肾上腺的三分之一自体移植到相应大腿。植入右侧缝匠肌的肾上腺在约1年后开始发挥功能，两侧股静脉皮质醇水平存在显著差异（分别为82.5和17.5微克/100毫升）证明了这一点。19-[131I]胆固醇扫描显示右侧大腿有肾上腺组织，而未发现肾上腺残余。手术后11年，患者无症状，无需替代治疗。我们发现，肾上腺自体移植是一种简单且无风险的手术，每当选择双侧肾上腺切除术治疗库欣病时都应考虑。
