Caputo R, Innocenti M, Gasparini G
J Cutan Pathol. 1980 Apr;7(2):61-9. doi: 10.1111/j.1600-0560.1980.tb01184.x.
The internal organization of plasma membranes was studied in seven subjects with pemphigus vulgaris and in one subject with familial pemphigus using the freeze-fracture technique. The results obtained seem to suggest that the acantholytic process is produced in a similar fashion whatever the pathogenic agent and that desmosomes represent the "target" membrane specializations in the acantholytic phenomena. The reduction and eventual disappearance of desmosomal particle aggregations is seemingly accompanied by an increase in gap junctions.
运用冷冻蚀刻技术，对7例寻常型天疱疮患者及1例家族性天疱疮患者的质膜内部结构进行了研究。所获结果似乎表明，无论致病因素如何，棘层松解过程均以类似方式发生，并且桥粒是棘层松解现象中“靶”膜特化结构。桥粒颗粒聚集体的减少及最终消失似乎伴随着缝隙连接的增加。
