Janik J, Seeler R A
J Pediatr Surg. 1980 Apr;15(2):117-20. doi: 10.1016/s0022-3468(80)80001-7.
During the 11 years between July, 1967 and June, 1978, 35 children with a major hemoglobinopathy (SS, SC, S-thalassemia) underwent 46 operations without any mortality or unusual morbidity. All of these children were prepared for surgery by preoperative transfusion of 15-20 cc/kg packed erythrocytes and a hematocrit of at least 36%. In urgent and emergent situations, the operation was performed as soon as the transfusion was completed. For elective patients, the operation was the following morning. The ease of application and the absence of morbidity and mortality suggest that this method of preoperative transfusion preparation of children with a major hemoglobinopathy is more desirable than a two-volume exchange or transfusions beginning 10-15 days prior to surgery.
在1967年7月至1978年6月的11年间，35名患有重度血红蛋白病（SS、SC、S-地中海贫血）的儿童接受了46次手术，无一例死亡或出现异常并发症。所有这些儿童术前均输注15 - 20 cc/kg浓缩红细胞，使血细胞比容至少达到36%，以此为手术做准备。在紧急和急症情况下，输血一完成便立即进行手术。对于择期手术的患者，手术于次日上午进行。这种方法应用简便，且无并发症和死亡情况，这表明对于患有重度血红蛋白病的儿童，这种术前输血准备方法比两次换血或在手术前10 - 15天开始输血更为可取。
