溶瘤呼肠孤病毒感染期间的遗传变异：野生型呼肠孤病毒的高代病毒株含有温度敏感突变体。
Genetic variation during lytic reovirus infection: high-passage stocks of wild-type reovirus contain temperature-sensitive mutants.
作者信息
Ahmed R, Chakraborty P R, Fields B N
出版信息
J Virol. 1980 Apr;34(1):285-7. doi: 10.1128/JVI.34.1.285-287.1980.
Abstract
Wild-type clones of reovirus serotypes 1 (Lang), 2 (Jones), and 3 (Dearing) were serially passaged in L cells at a high multiplicity of infection, and the virus population was examined at passage levels 2, 5, and 11 for the presence of temperature-sensitive (ts) mutants. By passage 11 all three serotypes contained ts mutants that were not present in the original wild-type stock. ts mutants representing three mutant groups were identified. The majority of these mutants were in group G. Our results show that high-passage stocks of reovirus consist of a genetically heterogeneous population.
摘要
呼肠孤病毒血清型1（朗株）、2（琼斯株）和3（迪林株）的野生型克隆在高感染复数下于L细胞中连续传代，并在第2、5和11代传代水平检测病毒群体中温度敏感（ts）突变体的存在情况。到第11代时，所有三种血清型均含有原始野生型毒株中不存在的ts突变体。鉴定出了代表三个突变组的ts突变体。这些突变体大多数属于G组。我们的结果表明，呼肠孤病毒的高传代毒株由基因异质性群体组成。
相似文献
1
Genetic variation during lytic reovirus infection: high-passage stocks of wild-type reovirus contain temperature-sensitive mutants.溶瘤呼肠孤病毒感染期间的遗传变异：野生型呼肠孤病毒的高代病毒株含有温度敏感突变体。
J Virol. 1980 Apr;34(1):285-7. doi: 10.1128/JVI.34.1.285-287.1980.
2
Genetic variation during persistent reovirus infection: presence of extragenically suppressed temperature-sensitive lesions in wild-type virus isolated from persistently infected L cells.呼肠孤病毒持续感染期间的基因变异：从持续感染的L细胞中分离出的野生型病毒中存在基因外抑制的温度敏感损伤。
J Virol. 1980 May;34(2):383-9. doi: 10.1128/JVI.34.2.383-389.1980.
3
Role of the host cell in persistent viral infection: coevolution of L cells and reovoirus during persistent infection.宿主细胞在持续性病毒感染中的作用：持续性感染期间L细胞与呼肠孤病毒的共同进化
Cell. 1981 Aug;25(2):325-32. doi: 10.1016/0092-8674(81)90050-7.
4
Persistent infections in L cells with temperature-sensitive mutants of reovirus.呼肠孤病毒温度敏感突变体在L细胞中的持续感染
J Virol. 1977 Aug;23(2):250-62. doi: 10.1128/JVI.23.2.250-262.1977.
5
Genetics of reovirus: the relationship of interference to complementation and reassortment of temperature-sensitive mutants at nonpermissive temperature.
Virology. 1979 Apr 15;94(1):119-27. doi: 10.1016/0042-6822(79)90442-2.
6
Genetic variation during persistent reovirus infection: isolation of cold-sensitive and temperature-sensitive mutants from persistently infected L cells.
Virology. 1983 Nov;131(1):71-8. doi: 10.1016/0042-6822(83)90534-2.
7
Revertants of temperature-sensitive mutants of reovirus: evidence for frequent extragenic suppression.
Virology. 1979 Jan 15;92(1):155-67. doi: 10.1016/0042-6822(79)90221-6.
8
Recombination between temperature-sensitive and deletion mutants of reovirus.呼肠孤病毒温度敏感型和缺失型突变体之间的重组
J Virol. 1976 Apr;18(1):117-23. doi: 10.1128/JVI.18.1.117-123.1976.
9
The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon.呼肠孤病毒1型的朗株和呼肠孤病毒3型的迪尔株对β干扰素的敏感性不同。
J Virol. 1991 Sep;65(9):5102-4. doi: 10.1128/JVI.65.9.5102-5104.1991.
10
Selection of a mutant S1 gene during reovirus persistent infection of L cells: role in maintenance of the persistent state.呼肠孤病毒持续感染L细胞期间突变S1基因的选择：在维持持续感染状态中的作用
Virology. 1983 Nov;131(1):79-87. doi: 10.1016/0042-6822(83)90535-4.
引用本文的文献
1
Viral Coinfections.病毒合并感染。
Viruses. 2022 Nov 26;14(12):2645. doi: 10.3390/v14122645.
2
Virological and Immunological Outcomes of Coinfections.病毒学和免疫学的合并感染结果。
Clin Microbiol Rev. 2018 Jul 5;31(4). doi: 10.1128/CMR.00111-17. Print 2018 Oct.
3
Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions.呼肠孤病毒sigmaNS蛋白是病毒装配复合体成核和病毒包涵体形成所必需的。
J Virol. 2001 Feb;75(3):1459-75. doi: 10.1128/JVI.75.3.1459-1475.2001.
4
Generation and role of defective proviruses in cytopathic feline leukemia virus (FeLV-FAIDS) infections.细胞病变型猫白血病病毒（FeLV - FAIDS）感染中缺陷前病毒的产生及其作用
J Virol. 1996 Jan;70(1):359-67. doi: 10.1128/JVI.70.1.359-367.1996.
5
Genetic variation during persistent reovirus infection: presence of extragenically suppressed temperature-sensitive lesions in wild-type virus isolated from persistently infected L cells.呼肠孤病毒持续感染期间的基因变异：从持续感染的L细胞中分离出的野生型病毒中存在基因外抑制的温度敏感损伤。
J Virol. 1980 May;34(2):383-9. doi: 10.1128/JVI.34.2.383-389.1980.
6
Tryptic peptide analysis of outer capsid polypeptides of mammalian reovirus serotypes 1, 2, and 3.哺乳动物呼肠孤病毒1、2和3型外衣壳多肽的胰蛋白酶肽分析
J Virol. 1981 Apr;38(1):208-18. doi: 10.1128/JVI.38.1.208-218.1981.
7
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.持续性感染小鼠脾脏中淋巴细胞性脉络丛脑膜炎病毒基因变体的选择。在抑制细胞毒性T淋巴细胞反应和病毒持续性中的作用。
J Exp Med. 1984 Aug 1;160(2):521-40. doi: 10.1084/jem.160.2.521.
8
The viral protein sigma 3 participates in translation of late viral mRNA in reovirus-infected L cells.病毒蛋白σ3参与呼肠孤病毒感染的L细胞中晚期病毒mRNA的翻译。
J Virol. 1987 Aug;61(8):2472-9. doi: 10.1128/JVI.61.8.2472-2479.1987.
9
Evolutionary variants of Rous sarcoma virus: large deletion mutants do not result from homologous recombination.劳氏肉瘤病毒的进化变体：大缺失突变体并非同源重组的结果。
J Virol. 1985 Jul;55(1):67-78. doi: 10.1128/JVI.55.1.67-78.1985.
本文引用的文献
1
2
A new attenuated rubella virus grown in human fibroblasts: evidence for reduced nasopharyngeal excretion.一种在人成纤维细胞中培养的新型减毒风疹病毒：鼻咽部排泄减少的证据。
Am J Epidemiol. 1967 Sep;86(2):468-77. doi: 10.1093/oxfordjournals.aje.a120757.
3
Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus.呼肠孤病毒温度敏感突变体的分离及初步遗传与生化特性分析
Virology. 1969 Mar;37(3):335-42. doi: 10.1016/0042-6822(69)90217-7.
4
Temperature-sensitive mutants of reovirus type 3: studies on the synthesis of viral RNA.呼肠孤病毒3型的温度敏感突变体：病毒RNA合成的研究
Virology. 1972 Dec;50(3):799-809. doi: 10.1016/0042-6822(72)90434-5.
5
Temperature-sensitive mutants of reovirus. VI. Mutant ts 447 and ts 556 particles that lack either one or two genome RNA segments.
Intervirology. 1974;3(1-2):36-46. doi: 10.1159/000149740.
6
Defective virions of reovirus.呼肠孤病毒的缺陷病毒粒子
J Virol. 1970 Aug;6(2):226-36. doi: 10.1128/JVI.6.2.226-236.1970.
7
Persistent infections in L cells with temperature-sensitive mutants of reovirus.呼肠孤病毒温度敏感突变体在L细胞中的持续感染
J Virol. 1977 Aug;23(2):250-62. doi: 10.1128/JVI.23.2.250-262.1977.
8
Interference of wild type virus replication by an RNA negative temperature-sensitive mutant of Semliki Forest virus.塞姆利基森林病毒的一种RNA负链温度敏感突变体对野生型病毒复制的干扰。
Virology. 1977 Jul 1;80(1):1-11. doi: 10.1016/0042-6822(77)90376-2.
9
Genetics of reovirus: identification of the ds RNA segments encoding the polypeptides of the mu and sigma size classes.呼肠孤病毒的遗传学：编码μ和σ大小类多肽的双链RNA片段的鉴定
Virology. 1978 Sep;89(2):594-604. doi: 10.1016/0042-6822(78)90200-3.
10
The nature of the polypeptide encoded by each of the 10 double-stranded RNA segments of reovirus type 3.呼肠孤病毒3型的10个双链RNA片段各自所编码的多肽的性质。
Virology. 1978 Sep;89(2):578-93. doi: 10.1016/0042-6822(78)90199-x.
Zotero 插件