Anderson C, Danylchuk K D
Calcif Tissue Res. 1978 Dec 8;26(2):143-8. doi: 10.1007/BF02013249.
This experiment was carried out in order to determine whether the chronic administration of low doses of cadmium resulted in an alteration of the haversian bone remodeling system in dogs. Two pairs of littermate beagles were administered 25 ppm cadmium chloride in their drinking water for 6 months. Four beagles matched for age and sex from the same colony served as controls. By means of fluorescent labeling, we measured haversian bone remodeling parameters according to the techniques described by Frost. Statistical analysis of the results showed significant changes at the 0.01 level in: activation frequency, appositional rates, and number of osteoid seams. At the 0.05 level, significant differences were found in the number of resorption spaces and the bone formation rate. In the absence of other evidence indicative of an alteration in the internal milieu of the dogs, it is concluded that a direct toxic action of cadmium on the mechanisms of activation of cells responsible for the creation and formation of new haversian systems cannot be excluded.
进行该实验是为了确定长期低剂量给予镉是否会导致犬哈弗斯骨重塑系统发生改变。两对同窝出生的比格犬在其饮用水中给予25 ppm氯化镉，持续6个月。从同一犬群中选取4只年龄和性别匹配的比格犬作为对照。通过荧光标记，我们根据弗罗斯特描述的技术测量了哈弗斯骨重塑参数。结果的统计分析显示，在激活频率、沉积速率和类骨质缝数量方面，在0.01水平有显著变化。在0.05水平，在吸收腔数量和骨形成率方面发现了显著差异。在没有其他表明犬体内环境改变的证据的情况下，得出结论，不能排除镉对负责新哈弗斯系统产生和形成的细胞激活机制具有直接毒性作用。
