An 18-month followup of students biologically at risk for psychiatric problems.

A prospective investigation using platelet monoamine oxidase activity and cortical evoked response augmenting/reducing to predict the onset of new episodes of affective disorders was conducted in a college sample. During an 18-month period between clinical interviews, higher incidences of major depression and hypomania characterized the low MAO/aociated with affective psychopathology in the original retrospective study.