Yoganathan A P, Reamer H H, Corcoran W H, Harrison E C
Scand J Thorac Cardiovasc Surg. 1980;14(1):1-5. doi: 10.3109/14017438009109849.
Thrombus formation on the aortic face of the disc and tissue overgrowth along the sewing ring adjacent to minor outflow region are major clinical pathologic findings observed with the present model Björk-Shiley aortic prosthesis. These pathologic findings may be attributed to the stagnation zone observed near the aortic face of the disc, and the low flow and shear in the minor outflow region of the prosthesis. In hope of reducing these pathologic conditions the new convexo-concave Björk-Shiley prosthesis was developed. In vitro velocity measurements made with a laser-Doppler anemometer in the immediate downstream vicinity of the convexo-concave Björk-Shiley aortic valve indicate that the design changes have decreased the size of the stagnation zone and have increased flow and shear in the minor outflow region. We conclude that the problems of thrombus formation and tissue overgrowth may be reduced in the new convexo-concave Björk-Shiley aortic valve.
在目前的Björk-Shiley主动脉瓣假体模型中观察到的主要临床病理表现为，瓣膜圆盘主动脉面形成血栓以及沿小流出区域附近的缝合环出现组织过度生长。这些病理表现可能归因于在瓣膜圆盘主动脉面附近观察到的停滞区，以及假体小流出区域的低血流和低剪切力。为了减少这些病理状况，研发了新型凸凹型Björk-Shiley瓣膜假体。用激光多普勒风速仪在凸凹型Björk-Shiley主动脉瓣紧邻下游处进行的体外速度测量表明，设计改变减小了停滞区的大小，并增加了小流出区域的血流和剪切力。我们得出结论，新型凸凹型Björk-Shiley主动脉瓣中血栓形成和组织过度生长的问题可能会减少。
