芳烃羟化酶被抗大鼠肝细胞色素P-450抗体所抑制。
Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450.
作者信息
Robie-Suh K, Robinson R, Gelboin H V, Guengerich F P
出版信息
Science. 1980 May 30;208(4447):1031-3. doi: 10.1126/science.7375915.
PMID:7375915
Abstract
Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells.
摘要
针对大鼠肝脏中由3-甲基胆蒽诱导产生的主要纯化细胞色素P-450的抗体，能强烈抑制未诱导及苯并[a]蒽诱导的人单核细胞和淋巴细胞的芳烃羟化酶活性。针对苯巴比妥诱导产生的细胞色素P-450的抗体，对相同人细胞的芳烃羟化酶活性影响相对较小或无影响。
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