氯化作用增强对二氧六环的毒性和酶抑制活性：立体选择性效应。
Enhancement of toxicity and enzyme-repressing activity of p-dioxane by chlorination: stereoselective effects.
作者信息
Woo Y T, Neuburger B J, Arcos J C, Argus M F, Nishiyama K, Griffin G W
出版信息
Toxicol Lett. 1980 Jan;5(1):69-75. doi: 10.1016/0378-4274(80)90150-2.
PMID:7376202
Abstract
The acute toxicity of p-dioxane may be enhanced up to 1000-fold by chlorination of the compound. The effect was stereoselective. Of the stereoisomers tested, tetrachloro-p-dioxane, isomer I (2r, 3t, 5t, 6c) was over 80 times more toxic than isomer II (2r, 3c, 5t, 6t). The latter compound was also a potent repressor of hepatic dimethylnitrosamine-demethylase I (DMN-d) and aryl hydrocarbon hydroxylase (AHH).
摘要
对二氧六环进行氯化处理后，其急性毒性可能会增强至原来的1000倍。这种效应具有立体选择性。在所测试的立体异构体中，四氯对二氧六环异构体I（2r，3t，5t，6c）的毒性比异构体II（2r，3c，5t，6t）高出80倍以上。后一种化合物还是肝脏二甲基亚硝胺脱甲基酶I（DMN-d）和芳烃羟化酶（AHH）的强效抑制剂。
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