Bouma D J, Kammer H
West J Med. 1980 Jan;132(1):13-5.
The effectiveness of methimazole used in a single daily dose was studied in 47 patients during their initial episode of hyperthyroidism, and in an additional eight patients during a relapse of hyperthyroidism. All patients become euthyroid using this method. Mean time required to achieve a euthyroid state was 16.7+/-1.1 weeks in the former group, and 14.9+/-2.9 weeks in the latter. In one patient there was an initial response to single daily dose therapy, but subsequently split dosage was required for control. The single daily dose regimen of antithyroid drugs will control hyperthyroidism in most patients. We have found that propylthiouracil will achieve this more rapidly than methimazole.
对47例初发甲亢患者及另外8例甲亢复发患者研究了每日单次剂量服用甲巯咪唑的有效性。采用该方法所有患者均恢复为甲状腺功能正常状态。前一组患者达到甲状腺功能正常状态所需的平均时间为16.7±1.1周，后一组为14.9±2.9周。有1例患者对每日单次剂量治疗起初有反应，但随后需要分剂量给药来控制病情。抗甲状腺药物每日单次剂量方案可控制大多数患者的甲亢。我们发现丙硫氧嘧啶比甲巯咪唑能更快达到这一效果。
