Pontiroli A E, Alberetto M, Pellicciotta G, De Castro e Silva E, De Pasqua A, Girardi A M, Pozza G
Acta Endocrinol (Copenh). 1980 Mar;93(3):271-6. doi: 10.1530/acta.0.0930271.
Prolactin (Prl) release, both in the experimental animal and in man, is stimulated by serotonin (5HT) and inhibited by dopamine (DA). Data also suggest that LH release in the animal is stimulated by norepinephrine and inhibited by DA. The role of 5HT in the control of LH release is less clear. It would appear to stimulate episodic LH release and to inhibit the LH surge at the pro-oestrus in animals, but the effect of 5HT on LH release has not yet been evaluated in man. In the present paper we have studied the effect of various DA-ergic drugs (DA, iv l-dopa, po l-dopa and bromoergocriptine) and of two anti-5HT drugs, metergoline and methysergide, on Prl and LH release in normal women. DA-ergic drugs lowered plasma Prl and LH levels; anti-5HT drugs, at doses able to lower Prl levels, did not affect basal LH release nor the inhibiting effect of iv l-dopa on LH release. These data indicate that DA inhibits both LH and Prl release in normal women, and that 5HT stimulates Prl release but is not involved in the regulation of LH secretion. The fact that, at variance to all the DA-ergic drugs used, the two anti-5HT drugs did not vary LH release, suggests that metergoline and methysergide are devoid of DA-ergic activity in man, at least at the doses able to inhibit Prl release.
在实验动物和人类中，催乳素（Prl）的释放受血清素（5HT）刺激，受多巴胺（DA）抑制。数据还表明，动物体内促黄体生成素（LH）的释放受去甲肾上腺素刺激，受DA抑制。5HT在控制LH释放中的作用尚不清楚。在动物中，它似乎能刺激LH的阵发性释放，并抑制发情前期的LH高峰，但5HT对人类LH释放的影响尚未得到评估。在本文中，我们研究了各种多巴胺能药物（DA、静脉注射左旋多巴、口服左旋多巴和溴隐亭）以及两种抗5HT药物美替拉酮和甲基麦角新碱对正常女性Prl和LH释放的影响。多巴胺能药物降低了血浆Prl和LH水平；抗5HT药物在能够降低Prl水平的剂量下，既不影响基础LH释放，也不影响静脉注射左旋多巴对LH释放的抑制作用。这些数据表明，DA在正常女性中抑制LH和Prl的释放，5HT刺激Prl释放，但不参与LH分泌的调节。与所有使用的多巴胺能药物不同，这两种抗5HT药物并未改变LH释放，这一事实表明，美替拉酮和甲基麦角新碱在人体内至少在能够抑制Prl释放的剂量下没有多巴胺能活性。
