Khalilullah M, Sathyamurthy I, Singhal N K
Am Heart J. 1980 Jun;99(6):766-71. doi: 10.1016/0002-8703(80)90627-4.
Six patients including three females with WPW syndrome (three with type A and three with type B) presenting with recurrent paroxysmal tachyarrhythmia were subject to electrophysiological studies. Apart from basal parameters, rapid atrial and ventricular pacing was done which confirmed electrophysiological characteristics of bundle of Kent operation. A single intravenous bolus of ajmaline 50 mg. was effective in blocking the bundle of Kent in all patients within 30 seconds of injection with the effect persisting for 15 minutes in one and from 25 to 60 minutes in the others. The most dramatic effect was prolongation of the HV interval with normalization of QRS complex with a marginal effect on the AH interval. The drug was also effective in breaking narrow QRS tachycardia in two patients and broad QRS tachycardia in one patient. Long-term oral therapy with ajmaline has proved effective in preventing recurrent tachyarrhythmias. We conclude that ajmaline is specifically effective and safe in the treatment of the WPW syndrome.
6例患者（包括3例女性）患有预激综合征（A型3例，B型3例），表现为反复发作的阵发性快速心律失常，接受了电生理研究。除基础参数外，还进行了快速心房和心室起搏，证实了肯特束手术的电生理特征。单次静脉注射50毫克阿义马林，所有患者在注射后30秒内均有效阻断肯特束，其中1例患者效果持续15分钟，其他患者效果持续25至60分钟。最显著的效果是HV间期延长，QRS波群正常化，对AH间期影响较小。该药物还成功终止了2例窄QRS波心动过速和1例宽QRS波心动过速。长期口服阿义马林已被证明可有效预防复发性快速心律失常。我们得出结论，阿义马林在治疗预激综合征方面具有特效且安全。
