Carney J A, Roth S I, Heath H, Sizemore G W, Hayles A B
Am J Pathol. 1980 May;99(2):387-98.
The histologic features of 21 parathyroid glands obtained from 16 Mayo Clinic patients aged 2 to 52 years who had multiple endocrine neoplasia type 2b (MEN 2b) were evaluated. The findings were correlated with the patients' ages and with the serum concentrations of calcium (15 patients), phosphorus (14 patients), and immunoreactive parathyroid hormone (iPTH) (11 patients), and with the response of serum iPTH to calcium infusion (6 patients). We also studied the histologic features of 13 parathyroid glands obtained from 8 patients not seen at the Mayo Clinic with MEN 2b. The microscopic appearance of the glands was normal in patients under the age of 17; with increased age, the glands did not exhibit normal involution, and an appearance consistent with mild chief-cell hyperplasia was evident. This abnormality was not associated with clinical or laboratory manifestations of hyperparathyroidism. We presently believe that parathyroidectomy for the disorder is not justified.
对来自梅奥诊所16例年龄在2至52岁、患有2b型多发性内分泌腺瘤病（MEN 2b）患者的21个甲状旁腺的组织学特征进行了评估。研究结果与患者年龄以及15例患者的血清钙浓度、14例患者的血清磷浓度、11例患者的免疫反应性甲状旁腺激素（iPTH）浓度相关，并与6例患者血清iPTH对钙输注的反应相关。我们还研究了来自8例未在梅奥诊所就诊的MEN 2b患者的13个甲状旁腺的组织学特征。17岁以下患者的甲状旁腺镜下外观正常；随着年龄增长，甲状旁腺未出现正常退化，明显呈现出与轻度主细胞增生一致的外观。这种异常与甲状旁腺功能亢进的临床或实验室表现无关。我们目前认为，针对该病症进行甲状旁腺切除术是不合理的。
