Kostreva D R, Castaner A, Kampine J P
Am J Physiol. 1980 May;238(5):R390-4. doi: 10.1152/ajpregu.1980.238.5.R390.
The reflex effects of hepatic low-pressure baroreceptors on renal and cardiopulmonary sympathetic efferent nerve activity were studied in mongrel dogs anesthetized with pentobarbital sodium. Systemic blood pressure, central venous pressure, hepatic, renal, and portal venous pressures were all measured during occlusion of the thoracic vena cava above the diaphragm, below the liver, and during occlusion of the portal vein. Renal and cardiopulmonary sympathetic efferent nerve activity was continuously recorded along with the hepatic efferent nerve activity during the caval occlusions. Hepatic baroreceptor excitation resulted in marked increases in hepatic afferent nerve activity and reflex increases in renal and cardiopulmonary sympathetic efferent nerve activity without a change in heart rate. Section of the anterior hepatic nerves eliminated the reflex increase in renal efferent nerve activity, but did not eliminate the increase in cardiopulmonary sympathetic efferent nerve activity. Carotid sinus denervation, bilateral cervical vagotomy, and phrenectomy did not alter the reflex responses to hepatic baroreceptor excitation. These hepatorenal and hepatocardiopulmonary reflexes may be important reflex mechanisms that are activated during congestive heart failure and cirrhosis of the liver.
在戊巴比妥钠麻醉的杂种犬中，研究了肝脏低压压力感受器对肾和心肺交感传出神经活动的反射效应。在膈上、肝下的胸段腔静脉闭塞期间以及门静脉闭塞期间，均测量了全身血压、中心静脉压、肝静脉压、肾静脉压和门静脉压。在腔静脉闭塞期间，连续记录肾和心肺交感传出神经活动以及肝传出神经活动。肝脏压力感受器兴奋导致肝传入神经活动显著增加，以及肾和心肺交感传出神经活动反射性增加，而心率无变化。切断肝前神经消除了肾传出神经活动的反射性增加，但未消除心肺交感传出神经活动的增加。颈动脉窦去神经支配、双侧颈迷走神经切断术和膈神经切除术均未改变对肝脏压力感受器兴奋的反射反应。这些肝肾和肝心肺反射可能是在充血性心力衰竭和肝硬化期间被激活的重要反射机制。
