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体力消耗和吲哚洛尔治疗引起的严重低血糖。病例报告。

Severe hypoglycaemia caused by physical strain and pindolol therapy. A case report.

作者信息

Uusitupa M, Aro A, Pietikäinen M

出版信息

Ann Clin Res. 1980 Feb;12(1):25-7.

PMID:7377753
Abstract

A 35-year-old man who was on treatment for mild arterial hypertension with the beta-blocking agent pindolol and who was accustomed to regular physical exercise, developed severe hypoglycaemia and bradycardia during a routine skiing tour. He recovered from the attack, and subsequent studies revealed no abnormalities of glucose metabolism. Apparently the hypoglycaemic attack was due to the combined effects of prolonged physical exercise of moderate degree and beta-blockade on glucose metabolism.

摘要

一名35岁男性,正在使用β受体阻滞剂吲哚洛尔治疗轻度动脉高血压,且习惯定期进行体育锻炼。在一次常规滑雪旅行中,他出现了严重低血糖和心动过缓。他从发作中恢复过来,随后的研究未发现葡萄糖代谢异常。显然,低血糖发作是由于适度的长时间体育锻炼和β受体阻滞剂对葡萄糖代谢的联合作用所致。

相似文献

1
Severe hypoglycaemia caused by physical strain and pindolol therapy. A case report.体力消耗和吲哚洛尔治疗引起的严重低血糖。病例报告。
Ann Clin Res. 1980 Feb;12(1):25-7.
2
[Severe hypoglycemia associated with physical strain in a patient using pindolol].[使用吲哚洛尔的患者中与体力活动相关的严重低血糖]
Duodecim. 1978;94(6):385-9.
3
[Treatment of hypertension with the beta-receptor-antagonist pindolol (Viskèn). A comparison with chlorthalidone (Hygroton)].用β受体拮抗剂吲哚洛尔(心得静)治疗高血压。与氢氯噻嗪(双氢克尿噻)的比较。
Ugeskr Laeger. 1973 May 17;135(20):971-4.
4
[Pressor reaction of hypertonic subjects to physical exercise of submaximal intensity under the influence of beta-adrenergic block (Pindolol) (author's transl)].[在β-肾上腺素能阻滞剂(吲哚洛尔)影响下,高血压患者对次最大强度体育锻炼的升压反应(作者译)]
Sb Lek. 1973 Oct;75(10):301-11.
5
Blood pressure reactivity in the evaluation of resting blood pressure and mood responses to pindolol and propranolol in hypertensive patients.高血压患者静息血压评估中的血压反应性以及对吲哚洛尔和普萘洛尔的情绪反应
Heart Lung. 1993 Sep-Oct;22(5):383-91.
6
[Study of the action of pindolol during rest and exertion on a group of subjects with hypertension].[心得安在休息及运动时对一组高血压患者作用的研究]
Ann Cardiol Angeiol (Paris). 1976 Oct;25(5):393-7.
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[Clinical test of a new beta-receptor blockader in labile hypertension].[一种新型β受体阻滞剂治疗不稳定型高血压的临床试验]
Verh Dtsch Ges Inn Med. 1971;77:940-3.
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Effects of long-term treatment with a beta-receptor blocker, pindolol, combined with a diuretic agent, clopamide, on exercise performance in hypertension.β受体阻滞剂吲哚洛尔与利尿剂氯噻酮长期联合治疗对高血压患者运动能力的影响。
Curr Med Res Opin. 1980;6(8):552-8. doi: 10.1185/03007998009109486.
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[Experience with the use of a beta-blocking agent in the community treatment of arterial hypertension].[β受体阻滞剂在社区治疗动脉高血压中的应用经验]
Clin Ter. 1981 Jun 15;97(5):521-7.
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[Preliminary trial of a beta-blocking agent (pindolol) in 3 schizophrenic patients and 3 non-psychotic psychiatric patients. Difference in sensitivity of heart rate].[β受体阻滞剂(吲哚洛尔)在3例精神分裂症患者和3例非精神病性精神科患者中的初步试验。心率敏感性差异]
Acta Psychiatr Belg. 1974 May;74(3):294-304.

引用本文的文献

1
Drug-induced hypoglycaemia: an update.药物诱导的低血糖症:更新。
Drug Saf. 2011 Jan 1;34(1):21-45. doi: 10.2165/11538290-000000000-00000.
2
Severe hypoglycaemia during physical exercise and treatment with beta-blockers.体育锻炼及使用β受体阻滞剂治疗期间的严重低血糖
Br Med J (Clin Res Ed). 1981 Apr 25;282(6273):1360. doi: 10.1136/bmj.282.6273.1360.
3
Exercise-induced hypoglycemia following propranolol in a patient after gastric fundoplication surgery.胃底折叠术后患者服用普萘洛尔后出现运动诱发的低血糖。
Dig Dis Sci. 1984 Dec;29(12):1164-6. doi: 10.1007/BF01317094.
4
Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics.肾上腺素能阻断会改变胰岛素依赖型糖尿病患者运动期间的葡萄糖动力学。
J Clin Invest. 1984 Jun;73(6):1648-58. doi: 10.1172/JCI111371.
5
Beta-adrenoceptor blockade and exercise. An update.β-肾上腺素能受体阻滞剂与运动。最新进展。
Sports Med. 1988 Apr;5(4):209-25. doi: 10.2165/00007256-198805040-00002.