Vishnevetskiĭ F E, Osipov A A
Arkh Patol. 1980;42(1):22-8.
The enzymatic activity of dehydrogenases and nonspecific esterases in skin affections in leprosy and their dynamics under the effect of treatment were investigated photometrically. It has been found that pentosophosphate pathway oxidation was mostly pronounced in microbe-containing macrophages of the infiltrate in untreated patients with the lepromatous type of leprosy and less according to the Krebs cycle and glycolysis. The intensity of oxidative processes is reduced under the influence of treatment, mainly, due to considerable inhibition of glycose-6-phosphatdehydrogenase. The activity of nonspecific esterases before the treatment is high in leprosy macrophages and low in the epidermis (as compared with the norm). Under the effect of antileprosy therapy the esterase content in the epidermis is restored and in the macrophages is decreased significantly.
用光度法研究了麻风病皮肤病变中脱氢酶和非特异性酯酶的酶活性及其在治疗作用下的动态变化。已发现，在未经治疗的瘤型麻风病患者中，浸润部位含微生物的巨噬细胞内戊糖磷酸途径氧化最为明显，而根据克雷布斯循环和糖酵解的氧化则较少。在治疗的影响下，氧化过程的强度降低，主要是由于葡萄糖-6-磷酸脱氢酶受到显著抑制。治疗前，麻风病巨噬细胞中非特异性酯酶的活性较高，而表皮中的活性较低（与正常情况相比）。在抗麻风病治疗的作用下，表皮中的酯酶含量恢复，而巨噬细胞中的酯酶含量则显著降低。
