David G
Arkh Patol. 1980;42(1):3-10.
Cellular pathology, one of the problems of natural science, is a part of theoretical bases on medicine. Created by R. Virchow in 1855, it has reached a new level, has acquired a new quality particularly in connection with the data obtained in the past 2 decades in investigations of the cell ultrastructure by special methods of electron microscopy. As a result, a hypothesis of diseases associated with organelles has arisen. Currently, mitochondrial and lysosomal diseases are gaining recognition. Examples of them are mitochondrial myopathies and accumulation diseases which can be not only congenital but be induced by lysosomotropic substances. "Organelle pathology" is closely associated with molecular pathology which is the most important basis of "organelle diseases".
细胞病理学是自然科学的问题之一，是医学理论基础的一部分。它由R. 魏尔啸于1855年创立，如今已达到一个新的水平，特别是与过去20年通过电子显微镜特殊方法对细胞超微结构研究中获得的数据相关联，从而具备了新的特质。结果，出现了与细胞器相关的疾病假说。目前，线粒体疾病和溶酶体疾病正逐渐得到认可。它们的例子有线粒体肌病和蓄积性疾病，这些疾病不仅可能是先天性的，还可能由溶酶体亲和性物质诱发。“细胞器病理学”与分子病理学密切相关，分子病理学是“细胞器疾病”最重要的基础。
