[Muscle relaxants / 3rd communication: Development of acrylic acid derivatives of potential muscle relaxing activity (author's transl)].

With reference to the occurrence of C=C partial structures and alkyl carboxylate groupings in muscle relaxants, the synthesis of acrylic acid derivatives by the aminomethinylation procedure has been followed up. From the reaction of s-triazine (1) with methyl acetoacetate (2a) and piperidine (5a), methyl 2-acetyl-3-piperidino acrylate (6a) arises. Analogously, 3-pyrrolidinoacrylophenone (6b) and 3-morpholinoacrylophenone (6c) are formed. In the same manner, the three-component reaction comprising the interaction of 1 with malononitrile (7) and a secondary amine (5) gives rise to the formation of the aminomethylenemalononitrile structure 8.