Woodside B, Leon M
J Comp Physiol Psychol. 1980 Feb;94(1):41-60. doi: 10.1037/h0077652.
Adrenalectomy-ovariectomy (adex-ovex) of mother rats resulted in prolonged nest bouts with their young. Glucocorticoid, but not progesterone or aldosterone, replacement therapy to adex-ovex dams limited the duration of maternal nesting bouts by successfully restoring the chronic vulnerability of these mother rats to the acute thermal consequences of huddling with the young. This vulnerability appeared to be due to a chronic elevation of maternal temperature. When the heat load of hormone-disrupted mothers was chronically elevated, the dams were subject to an acute rise in temperature while huddling with their young, and nest bouts were curtailed.
切除母鼠的肾上腺和卵巢（肾上腺-卵巢切除术）会导致其与幼崽在一起筑巢的时间延长。对接受肾上腺-卵巢切除术的母鼠进行糖皮质激素替代治疗，而非孕酮或醛固酮替代治疗，通过成功恢复这些母鼠因与幼崽依偎而产生的急性热效应的慢性易感性，限制了母性筑巢行为的持续时间。这种易感性似乎是由于母鼠体温长期升高所致。当激素紊乱的母鼠的热负荷长期升高时，母鼠在与幼崽依偎时体温会急剧上升，从而缩短筑巢时间。
