苯妥英治疗患者白细胞中δ-氨基乙酰丙酸合酶的诱导——与大鼠肝组织变化的比较
Induction of delta-aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy--comparison with changes in rat hepatic tissue.
作者信息
McColl K E, Moore M R, Thompson G G, Goldberg A
出版信息
Br J Clin Pharmacol. 1980 Apr;9(4):327-31. doi: 10.1111/j.1365-2125.1980.tb01058.x.
Abstract
1 In rats daily phenytoin (DPH) administration resulted in an increase in hepatic cytochrome P450 content. The rise in cytochrome P450 was associated with a temporary increase in the acitvity of hepatic delta-aminolaevulinic acid (ALA) synthase. 2 In patients newly commenced on DPH anticonvulsant therapy the activity of ALA synthase in peripheral leucocytes showed a marked temporary increase during the first 10 days of therapy. 3 These findings suggest that DPH induces a haem-requiring eenzyme system in peripheral leucocytes as well as in hepatic tissue.
摘要
- 在大鼠中，每日给予苯妥英钠（DPH）会导致肝脏细胞色素P450含量增加。细胞色素P450的增加与肝脏δ-氨基乙酰丙酸（ALA）合酶活性的短暂增加有关。2. 对于刚开始接受DPH抗惊厥治疗的患者，外周血白细胞中ALA合酶的活性在治疗的前10天显示出明显的短暂增加。3. 这些发现表明，DPH在外周血白细胞以及肝脏组织中诱导了一种需要血红素的酶系统。
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