Gregg P J, Walder D N, Rannie I
Br J Exp Pathol. 1980 Feb;61(1):39-54.
Investigation of the exact aetiology, early diagnosis and prevention of caisson disease of bone has been hindered by the inability to produce, by the use of realistic compression/decompression exposures, truly comparable lesions in animals. Four Gottingen mini-pigs were subjected to repeated exposures to pressures of 27 p.s.i.g. for 6 h over a period of 9 months and decompressed according to standard tables. Two mini-pigs acted as controls. In one animal radiological changes were recognised in the left lower femoral shaft 19 weeks after the exposures were started and subsequent examination of that bone confirmed the presence, at that site, of a lesion which macroscopically and microscopically resembled, in every way, the appearances of those seen in the shafts of long bones in man. It is concluded therefore that, properly used, the mini-pig may be a suitable animal model for the study of this condition in man.
由于无法通过使用实际的加压/减压暴露在动物身上产生真正可比的病变，骨减压病的确切病因、早期诊断和预防的研究受到了阻碍。四只哥廷根小型猪在9个月的时间里反复暴露于27磅/平方英寸表压下6小时，并根据标准表格进行减压。两只小型猪作为对照。在一只动物中，在开始暴露19周后，左股骨干下部出现了放射学变化，随后对该骨骼的检查证实，在该部位存在一个病变，该病变在宏观和微观上与人类长骨干中所见的外观在各方面都相似。因此得出结论，正确使用的话，小型猪可能是研究人类这种疾病的合适动物模型。
