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通过结合胆红素的光谱变化监测人血清白蛋白中性转变的热力学和动力学

Thermodynamics and kinetics of the neutral transition of human serum albumin, monitored by the spectral change of bound bilirubin.

作者信息

Jacobsen J, Faerch T

出版信息

Biochim Biophys Acta. 1980 May 29;623(1):199-207. doi: 10.1016/0005-2795(80)90021-5.

DOI:10.1016/0005-2795(80)90021-5
PMID:7378470
Abstract

Sectral changes in the complex of human serum albumin with bilirubin in the neutral pH range are related to conformational alterations of the protein. The transformation responds to changes in temperature and concentration of calcium ions in a similar fashion as the N-B transition of albumin. The kinetics of the structural changes are studied. The spectral shift from high to low, as well as from low to high pH, is presented in a model consisting of three relaxation steps.

摘要

在中性pH范围内，人血清白蛋白与胆红素复合物的光谱变化与蛋白质的构象改变有关。这种转变对温度和钙离子浓度变化的响应方式与白蛋白的N - B转变相似。研究了结构变化的动力学。在一个由三个弛豫步骤组成的模型中呈现了从高pH到低pH以及从低pH到高pH的光谱位移。

相似文献

1
Thermodynamics and kinetics of the neutral transition of human serum albumin, monitored by the spectral change of bound bilirubin.通过结合胆红素的光谱变化监测人血清白蛋白中性转变的热力学和动力学
Biochim Biophys Acta. 1980 May 29;623(1):199-207. doi: 10.1016/0005-2795(80)90021-5.
2
Stopped-flow studies of spectral changes in bilirubin-human serum albumin following an alkaline pH jump and following binding of bilirubin.
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Albumin-bilirubin binding mechanism.白蛋白-胆红素结合机制。
J Biol Chem. 1983 May 25;258(10):6319-26.
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Spectroscopic properties of bilirubin-human serum albumin complexes: a stoichiometric analysis.
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Affinity labeling of the primary bilirubin binding site of human serum albumin.
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Kinetics of neutral transition of human serum albumin.
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Conformational changes in the bilirubin-human serum albumin complex at extreme alkaline pH.在极端碱性pH条件下胆红素-人血清白蛋白复合物的构象变化
Biochem J. 1986 Jun 1;236(2):365-9. doi: 10.1042/bj2360365.
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Bilirubin binding by primary sites of human serum albumin, with suppression of secondary-site interference by use of a high salt concentration.
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Kinetics and mechanism of bilirubin binding to human serum albumin.胆红素与人类血清白蛋白结合的动力学及机制
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Role of salt bridge(s) in the binding and photoconversion of bilirubin bound to high affinity site on human serum albumin.盐桥在胆红素与人血清白蛋白高亲和力位点结合及光转化中的作用
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引用本文的文献

1
Conformational changes in human serum albumin studied by fluorescence and absorption spectroscopy. Distance measurements as a function of pH and fatty acids.通过荧光和吸收光谱法研究人血清白蛋白的构象变化。作为pH值和脂肪酸函数的距离测量。
Biochem J. 1989 Feb 15;258(1):199-204. doi: 10.1042/bj2580199.