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离子载体介导的阳离子在人工体系中的转运。II. - X537A介导的钙和钠的转运。

Ionophore-mediated cation translocation in artificial systems. II. - X537A-mediated calcium and sodium translocation.

作者信息

Couturier E, Malaisse W J

出版信息

Biochimie. 1980;62(2-3):177-80. doi: 10.1016/s0300-9084(80)80193-3.

DOI:10.1016/s0300-9084(80)80193-3
PMID:7378478
Abstract

The ionophore X537A translocates both calcium and sodium from an aqueous into an organic solution. At non saturating cationic concentrations, each atom of calcium seems to react with two molecules of ionophore, whereas each atom of sodium apparently reacts with only one molecule of X537A. The phenomena of sodium and calcium translocation, respectively, are competitive and are both inhibited when the pH of the aqueous phase is decreased.

摘要

离子载体X537A可将钙和钠从水相转运至有机相。在非饱和阳离子浓度下,每个钙原子似乎与两个离子载体分子发生反应,而每个钠原子显然仅与一个X537A分子发生反应。钠和钙的转运现象各自具有竞争性,并且当水相的pH降低时二者均受到抑制。

相似文献

1
Ionophore-mediated cation translocation in artificial systems. II. - X537A-mediated calcium and sodium translocation.离子载体介导的阳离子在人工体系中的转运。II. - X537A介导的钙和钠的转运。
Biochimie. 1980;62(2-3):177-80. doi: 10.1016/s0300-9084(80)80193-3.
2
Cation and local anesthetic conductance induced by the negatively charged ionophore Br-X537A in lipid bilayers.带负电荷的离子载体Br-X537A在脂质双分子层中诱导的阳离子和局部麻醉剂电导。
Can J Biochem. 1982 Jan;60(1):49-56. doi: 10.1139/o82-008.
3
Synergistic effects of hypoglycaemic sulphonylureas and antibiotic ionophores upon calcium translocation.降血糖磺脲类药物与抗生素离子载体对钙转运的协同作用。
Br J Pharmacol. 1980;71(1):315-20. doi: 10.1111/j.1476-5381.1980.tb10941.x.
4
Structural and kinetic studies of lasalocid A (X537A) and its silver, sodium, and barium salts in nonpolar solvents.拉沙洛西A(X537A)及其银盐、钠盐和钡盐在非极性溶剂中的结构与动力学研究。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1786-90. doi: 10.1073/pnas.73.6.1786.
5
Exchange diffusion of dopamine induced in planar lipid bilayer membranes by the ionophore X537A.离子载体X537A在平面脂质双分子层膜中诱导的多巴胺交换扩散。
J Gen Physiol. 1977 May;69(5):633-53. doi: 10.1085/jgp.69.5.633.
6
Free acid, anion, alkali, and alkaline earth complexes of lasalocid a (X537A) in methanol: structural and kinetic studies at the monomer level.拉沙洛西A(X537A)在甲醇中的游离酸、阴离子、碱和碱土金属配合物:单体水平的结构和动力学研究
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4277-81. doi: 10.1073/pnas.73.12.4277.
7
Ionophore-mediated cation translocation in artificial systems. I. A23187-mediated calcium translocation.
Biochimie. 1979;61(10):1185-92. doi: 10.1016/s0300-9084(80)80232-x.
8
Surface properties of membrane systems: interaction of electrolyte and lipid with Ca2+ ionophores.膜系统的表面性质:电解质和脂质与钙离子载体的相互作用
J Pharm Sci. 1980 Apr;69(4):406-9. doi: 10.1002/jps.2600690411.
9
The stoichiometry of A23187- and X537A-mediated calcium ion transport across lipid bilayers.A23187 和 X537A 介导的钙离子跨脂质双层转运的化学计量学。
Biochim Biophys Acta. 1984 Nov 21;778(1):219-23. doi: 10.1016/0005-2736(84)90465-6.
10
Inhibition of lipolysis in hamster adipocytes by the cation ionophor X537A.
J Cyclic Nucleotide Res. 1979;5(4):327-38.

引用本文的文献

1
Formation of hybrid complexes between Ca and the ionophores bromolasalocid (Br-X537A) and A23187.钙与离子载体溴莫拉唑西(Br-X537A)和 A23187 形成的混合配合物。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):279-82. doi: 10.1073/pnas.78.1.279.
2
Synergistic effects of hypoglycaemic sulphonylureas and antibiotic ionophores upon calcium translocation.降血糖磺脲类药物与抗生素离子载体对钙转运的协同作用。
Br J Pharmacol. 1980;71(1):315-20. doi: 10.1111/j.1476-5381.1980.tb10941.x.
3
Insulinotropic effects of hypoglycaemic and hyperglycaemic sulphonamides: the ionophoretic hypothesis.
低血糖和高血糖磺酰胺类药物的促胰岛素分泌作用:离子载体假说
Diabetologia. 1980 Oct;19(4):335-40. doi: 10.1007/BF00280516.