Baskova I P, Cherkesova D U, Mosolov B B, Malova E L, Belianova L A
Biokhimiia. 1980 Mar;45(3):463-7.
In contrast to hirudin, "pseudohirudin", which is practically devoid of the antithrombin activity, is represented as associates of di- and trimers. The molecular weight of the "pseudohirudin" monomer is by 2000 less than that for hirudin. This corresponds to the 20 amino acid residues difference calculated from the total number of the amino acid residues. Changes in the amino acid composition consist in a higher content of dicarboxylic amino acids, isoleucine, lysine, tyrosine and cystein in the hirudin preparations.
与水蛭素不同，几乎没有抗凝血酶活性的“假水蛭素”表现为二聚体和三聚体的缔合体。“假水蛭素”单体的分子量比水蛭素的分子量小2000。这与根据氨基酸残基总数计算出的20个氨基酸残基的差异相对应。水蛭素制剂中氨基酸组成的变化在于二羧酸氨基酸、异亮氨酸、赖氨酸、酪氨酸和半胱氨酸的含量较高。
