[Lipoperoxidation in the hyperactive focus of rat cerebral cortex].

The possibility of participation of lipoperoxidation (LPO) in the mechanisms of development of epileptic activity in rat cerebral cortex has been shown. The appearance of epileptic activity after penicillin application to the sensorimotor cortex induced a considerable increase in the concentration of LPO products in the crude synaptosomal fraction from the hyperactive focus. Preliminary injection to rats of the antioxidant alpha-tocopherol abolished the effect of LPO activation and decreased the number of seizures recorded on the electrocorticogram in the course of the focus existence.