钙拮抗血管扩张剂硝苯地平与维拉帕米对犬气管肌肉组织和血管系统的不同作用
Differential effects of the calcium-antagonistic vasodilators, nifedipine and verapamil, on the tracheal musculature and vasculature of the dog.
作者信息
Himori N, Taira N
出版信息
Br J Pharmacol. 1980 Apr;68(4):595-7. doi: 10.1111/j.1476-5381.1980.tb10848.x.
Abstract
In anaesthetized dogs the trachea in situ was perfused arterially with blood, and drugs were injected intraarterially. Isoprenaline and the calcium-antagonistic vasodilators, nifedipine and verapamil, increased tracheal blood flow and decreased resting tone of the trachea. Isoprenaline was equi-effective in producing tracheal vasodilatation and tracheal dilatation. The two calcium-antagonistic vasodilators were less effective tracheal dilators than tracheal vasodilators.
摘要
在麻醉犬中，对原位气管进行动脉灌注血液，并经动脉注射药物。异丙肾上腺素以及钙拮抗型血管扩张剂硝苯地平和维拉帕米可增加气管血流量并降低气管的静息张力。异丙肾上腺素在产生气管血管舒张和气管扩张方面具有同等效力。两种钙拮抗型血管扩张剂作为气管扩张剂的效果不如作为气管血管扩张剂的效果好。
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