在血管分离的猫颈动脉窦用普萘洛尔进行超灌注期间猫的心脏下神经活动。
Inferior cardiac nerve activity in the cat during superfusion of the vascularly isolated carotid sinus with propranolol.
作者信息
McCleary M, Tuttle R S
出版信息
Br J Pharmacol. 1980 Apr;68(4):779-81. doi: 10.1111/j.1476-5381.1980.tb10872.x.
Abstract
1 Inferior cardiac nerve activity in 9 cats was in inverse relationship to the pressure maintained in the systemically isolated and perfused carotid sinus. 2 Perfusion with propranolol produced no change in this relationship at a concentration of 5.0 microgram/ml, but abolished it at 50.0 microgram/ml. 3 The results suggest that concentrations of propranolol which have been reported to enhance the sensitivity of the carotid sinus to pressure do not enhance one neurophysiological component of the reflex depressor response.
摘要
- 9只猫的心脏下神经活动与全身分离并灌注的颈动脉窦内维持的压力呈反比关系。2. 以5.0微克/毫升的浓度用普萘洛尔灌注，这种关系没有变化，但在50.0微克/毫升时这种关系消失。3. 结果表明，据报道可增强颈动脉窦对压力敏感性的普萘洛尔浓度，并未增强反射性降压反应的一种神经生理成分。
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A mechanism to explain the antihypertensive action of propranolol.一种解释普萘洛尔降压作用的机制。
J Pharmacol Exp Ther. 1978 Oct;207(1):56-63.
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