Gutwein B M, Fishbein W
Brain Res Bull. 1980 Mar-Apr;5(2):105-9. doi: 10.1016/0361-9230(80)90180-x.
Sleep cycle circadian rhythmicity following either enriched or impoverished environmental rearing is examined in this study. Mice are reared in either super-enriched (SEE), regular-enriched (REE), social control (SC), or impoverished (IE) environments for 30 days. SEE and REE groups show a general increase in total slow-wave sleep (SWS) in the 24 hr cycle but the number of SWS episodes, mean duration of SWS episodes, and percent SWS of total sleep time (TST) is not significantly different from the SC groups for the Day cycle (0700--1900). Enriched rearing produces a selective and significant increase in the number of PS (Paradoxical sleep or REM sleep) episodes, mean duration of PS episodes, total amount of PS time, and percent PS/TST throughout the 24 hr cycle. IE reared mice also show a general increase in SWS primarily during the Day cycle but with rearing experience plays an important role in the developing of the basic rhythmicity during the sleep (PS-SWS)-wakefulness cycle, and (2) provide further support for our hypothesis that PS occurring over a prolonged time period is a requisite neurobiological mechanism for the processing, maintenance, and storage of long-term memory.
本研究考察了在丰富或贫乏环境饲养后睡眠周期的昼夜节律。将小鼠饲养在超丰富（SEE）、常规丰富（REE）、社会对照（SC）或贫乏（IE）环境中30天。SEE组和REE组在24小时周期内总的慢波睡眠（SWS）普遍增加，但在白天周期（0700 - 1900），SWS发作次数、SWS发作平均持续时间以及SWS占总睡眠时间（TST）的百分比与SC组无显著差异。丰富饲养在整个24小时周期内使快速眼动睡眠（PS，即异相睡眠或快速眼动睡眠）发作次数、PS发作平均持续时间、PS总时长以及PS/TST百分比有选择性且显著增加。IE饲养的小鼠在白天周期SWS也普遍增加，但饲养经历在睡眠（PS - SWS） - 觉醒周期的基本节律形成中起重要作用，并且（2）为我们的假设提供了进一步支持，即长时间的PS是长期记忆加工、维持和存储所必需的神经生物学机制。
