伴有骨转移的癌症患者血清酸性磷酸酶升高。
Elevation of serum acid phosphatase in cancers with bone metastasis.
作者信息
Tavassoli M, Rizo M, Yam L T
出版信息
Cancer. 1980 May 1;45(9):2400-3. doi: 10.1002/1097-0142(19800501)45:9<2400::aid-cncr2820450927>3.0.co;2-n.
In patients with nonprostatic cancer serum acid phosphatase activity is usually elevated when bone metastasis is present but not when bone metastasis is absent. The fraction responsible for serum enzyme elevation is a normal component of serum; it appears in gel electrophoresis as band 5; and is tartrate-resistant. It is suggested that the origin of acid phosphatase elevation is bone osteoclasts rather than cancer tissue, as is the case with prostatic carcinoma. Determination of serum acid phosphatase activity may be useful in the detection of bone metastasis.
在非前列腺癌患者中，存在骨转移时血清酸性磷酸酶活性通常会升高，而无骨转移时则不会升高。导致血清酶升高的部分是血清的正常成分；在凝胶电泳中显示为5条带；且对酒石酸具有抗性。有人认为，酸性磷酸酶升高的来源是骨破骨细胞而非癌组织，这与前列腺癌的情况不同。测定血清酸性磷酸酶活性可能有助于检测骨转移。
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