衰老、红细胞表面唾液酸及糖肽对人体自身玫瑰花结的影响。
Effects of ageing, surface sialic acid and glycopeptides of erythrocytes on auto-rosettes in man.
作者信息
Fabia F, Gattegno L, Gluckman J C, Cornillot P
出版信息
Clin Exp Immunol. 1978 Nov;34(2):295-301.
Human red blood cells can bind in vitro to autologous peripheral blood lymphocytes forming auto-rosettes. The percentage of rosett-forming cells (A-RFC) depends on erythrocyte ageing in vivo. Old untreated cells given an A-RFC percentage lower as compared with the young ones. The same age groups of cells treated with neuraminidase show a parallel increase of A-RFC as compared with untreated cells. No significant difference is found between young and old cells with high concentrations of neuraminidase. The rosetting formation is inhibited by the pre-treatment of lymphocytes with erythrocyte glycopeptides released by trypsin. This suggests that auto-rosetting is mediated by erythrocyte surface glycopeptides in which sialic acid plays a role directly or not.
人红细胞在体外可与自身外周血淋巴细胞结合形成自身玫瑰花结。形成玫瑰花结细胞（A-RFC）的百分比取决于体内红细胞的老化程度。未经处理的衰老细胞形成的A-RFC百分比低于年轻细胞。用神经氨酸酶处理的相同年龄组细胞与未处理细胞相比，A-RFC呈平行增加。高浓度神经氨酸酶处理的年轻细胞和衰老细胞之间未发现显著差异。用胰蛋白酶释放的红细胞糖肽预处理淋巴细胞可抑制玫瑰花结的形成。这表明自身玫瑰花结形成是由红细胞表面糖肽介导的，其中唾液酸直接或间接发挥作用。
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