Cramp D G, Tickner T R, Wills M R
Lancet. 1976 Jul 24;2(7978):176-81. doi: 10.1016/s0140-6736(76)92348-5.
A scheme is advanced whereby plasma-lipoproteins form an integrated controlled pathway for storage of energy as triglyceride. The importance of insulin within this system is indicated and the consequence of possible errors considered. Changes secondary to organ disease are found to fit within the proposed pathway. Although many refinements remain to be added, this hypothesis seems to form a plausible framework within which lipoprotein abnormality and the underlying condition may be better understood and thereby treated.
提出了一种设想,即血浆脂蛋白形成一条整合的受控途径,用于将能量储存为甘油三酯。指出了胰岛素在该系统中的重要性,并考虑了可能出现错误的后果。发现器官疾病继发的变化符合所提出的途径。尽管仍有许多细节有待补充,但这一假说似乎形成了一个合理的框架,在这个框架内,脂蛋白异常及潜在病症可能会得到更好的理解,从而得到治疗。