Titov V N, Sanfirova V M, Khodakova T D
Farmakol Toksikol. 1980 Jan-Feb;43(1):84-8.
The cholestyramine effect on the biosynthesis of lipids and lipoproteins in the rat liver was investigated in order to elucidate the mechanisms of serum triglyceride concentration increase. Cholestyramine feeding produces an increase in the biosynthesis of neutral lipids by the liver and a considerable rise in specific radioactivity of serum free cholesterol and triglycerides. Cholestyramine intensifies the biosynthesis of apoproteins of very low density lipoproteins (VLDL), formation of lipoproteins and their secretion into the blood. Increased secretion of newly synthesized VLDL, the major component of which are triglycerides, leads to hypertriglyceridemia.
为阐明血清甘油三酯浓度升高的机制，研究了消胆胺对大鼠肝脏脂质和脂蛋白生物合成的影响。喂食消胆胺会使肝脏中性脂质的生物合成增加，血清游离胆固醇和甘油三酯的比放射性显著升高。消胆胺会增强极低密度脂蛋白（VLDL）载脂蛋白的生物合成、脂蛋白的形成及其向血液中的分泌。新合成的VLDL（其主要成分是甘油三酯）分泌增加会导致高甘油三酯血症。
