Korkhov V V, Makusheva V P, Nikitin A I
Farmakol Toksikol. 1980 Jan-Feb;43(1):94-6.
It has been shown experimentally that a combined use of estrogen-norsteroids prostaglandins and neurotropic substances during preimplantation period produces the most potent contraceptive effect. Analysis of the action mode of combined small doses of steroids, prostaglandins and neurotropic drugs suggests that the contraceptive action is underlain by the inhibitory effect on incretion produced by the luteinizing hormone, this effect being in its turn a reason for variation in the amount and condition of the developing fetuses.
实验表明，在植入前期联合使用雌激素-去甲甾体类、前列腺素和神经营养物质可产生最强的避孕效果。对小剂量甾体类、前列腺素和神经营养药物联合作用方式的分析表明，其避孕作用的基础是对促黄体生成素分泌的抑制作用，而这种作用反过来又是发育中胎儿数量和状况变化的原因。
