Dryden R J
Dev Med Child Neurol. 1980 Apr;22(2):234-43. doi: 10.1111/j.1469-8749.1980.tb04334.x.
The possible embryogenesis of diplomyelia is discussed in the context of the current understanding of neurulation. The mechanisms of normal development of the neural tube differ from one region to another, so the initial step in development of diplomyelia will probably depend on the location of the lesion. In the cranial portion of the neural tube, abnormal folding of the neural plate is most likely to be responsible for the formation of supernumerary lumina. In the intermediate transitional region, the neural plate diminishes as the contribution from the end bud increases, so errors might originate in either or both of these structures. In the caudal region of the embryo, the neural tube is established by canalization of the solid medullary cord, so diplomyelia in this region is most likely to stem from faulty canalization. Once the sub-populations of neural cells have been established, their subsequent physical separation appears to be due to changes in the region between the adjacent lumina, for example enlargement of intercellular spaces and degeneration of neural cells.
本文在当前对神经胚形成的理解背景下，讨论了脊髓纵裂可能的胚胎发生机制。神经管正常发育的机制因区域而异，因此脊髓纵裂发育的初始步骤可能取决于病变的位置。在神经管的头端部分，神经板的异常折叠最有可能导致多余管腔的形成。在中间过渡区域，随着尾芽贡献的增加，神经板会缩小，因此错误可能源于这两个结构中的一个或两个。在胚胎的尾端区域，神经管是通过实心髓索的管道化形成的，因此该区域的脊髓纵裂最有可能源于管道化错误。一旦神经细胞亚群形成，它们随后的物理分离似乎是由于相邻管腔之间区域的变化，例如细胞间空间的扩大和神经细胞的退化。
