肝脏疾病循环免疫复合物的研究。5. 抗DNA抗体与C1q结合活性

Studies on circulating immune complexes of the liver diseases. 5. Anti-DNA antibodies and C1q binding activity.

作者信息

Arima T, Narumoto J, Shimomura H, Yasuhara T, Kunishi K, Suwaki K, Nagashima H

出版信息

Gastroenterol Jpn. 1980 Apr;15(2):167-172. doi: 10.1007/BF02774932.

Abstract

Anti-dsDNA and anti-ssDNA antibodies, rheumatoid factors, HBsAg and C1q binding activity were determined in sera of patients with various liver diseases. Anti-dsDNA were only slightly increased in chronic aggressive hepatitis, activity severe and liver cirrhosis. A moderate elevation of anti-dsDNA was detected in possible lupoid hepatitis and it was highly increased in lupoid hepatitis as well as systemic lupus erythematosus. Non-specific elevation of anti-ssDNA titers were observed in all of the liver disease groups. In patients with increased anti-dsDNA titers, C1q binding activity and titers for rheumatoid factor and HBsAg tended to increase. According to reactivity of their sera to DNA, patients with liver disease could be divided in 4 groups: 1. high responders to dsDNA (lupoid hepatitis), 2. moderate responders to dsDNA (possible lupoid hepatitis or lupoid-like liver disease), 3. low responders (only positive for ssDNA), and 4. non-responders.

摘要

在各类肝病患者的血清中检测了抗双链DNA和抗单链DNA抗体、类风湿因子、乙肝表面抗原及C1q结合活性。在慢性侵袭性肝炎、重度活动性肝炎和肝硬化患者中，抗双链DNA仅略有升高。在可能的狼疮样肝炎患者中检测到抗双链DNA中度升高，在狼疮样肝炎以及系统性红斑狼疮患者中其高度升高。在所有肝病组中均观察到抗单链DNA滴度的非特异性升高。抗双链DNA滴度升高的患者，其C1q结合活性以及类风湿因子和乙肝表面抗原滴度往往也会升高。根据患者血清对DNA的反应性，肝病患者可分为4组：1. 双链DNA高反应者（狼疮样肝炎），2. 双链DNA中度反应者（可能的狼疮样肝炎或狼疮样肝病），3. 低反应者（仅单链DNA呈阳性），4. 无反应者。