蛔虫肌肉中药物反应的特异性（作者译）
[The specificity of pharmacological responses in Ascaris muscle (author's transl)].
作者信息
Hayashi E, Haruno A, Shimizu T, Terada M
出版信息
Nihon Yakurigaku Zasshi. 1980 Jan;76(1):15-24.
To investigate the pharmacological properties of Ascaris muscle, comparative studies were undertaken on the actions of various drugs on Ascaris muscle, guinea pig isolated ileum and frog isolated rectus preparations. In Ascaris muscle and frog isolated rectus preparations, the contractile activities with acetylcholine (ACh, 10(-5) g/ml in Ascaris and 10(-6) g/ml in frog rectus) and 1, 1-dimethyl-4-phenylpiperazinium (DMPP, 10(-6) g/ml) were inhibited significantly and reversely by d-tubocurarine (d-Tc, 10(-5) g/ml) and mecamylamine (Meca, 10(-5) g/ml), and slightly by atropine (Atr, 10(-4) g/ml) and hexamethonium (C6, 10(-4) g/ml). In guinea pig isolated ileum preparation, the contractile activity with ACh (10(-6) g/ml) was inhibited markedly and reversely but Atr (10(-6) g/ml), while the activity with DMPP (10(-6) g/ml) was similarly inhibited by Meca (10(-6) g/ml), C6 (10(-6) g/ml) and Atr (10(-6) g/ml). Although frog isolated rectus preparation was contracted with 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium (McN-A-343, 10(-5) g/ml) but not with pilocarpine (10(-4) g/ml), Ascaris muscle preparation was not affected by these agonists. Frog isolated rectus preparation was contracted with 5-hydroxytryptamine (5 HT, 10(-4) g/ml) but was not affected by histamine (His, 10(-3) g/ml) and gamma-aminobutyric acid (GABA, 10(-4) g/ml), whereas Ascaris muscle was contracted with His (10(-3) g/ml) and relaxed with 5-HT (10(-4) g/ml) and GABA (10(-5) g/ml). These results suggest that Ascaris muscle as well as skeletal muscle have nicotinic receptors and that the Ascaris muscle has properties which differ specifically from skeletal muscle.
为研究蛔虫肌肉的药理特性，对多种药物作用于蛔虫肌肉、豚鼠离体回肠和青蛙离体腹直肌标本进行了比较研究。在蛔虫肌肉和青蛙离体腹直肌标本中，乙酰胆碱（蛔虫中为10⁻⁵ g/ml，青蛙腹直肌中为10⁻⁶ g/ml）和1,1 - 二甲基 - 4 - 苯基哌嗪鎓（DMPP，10⁻⁶ g/ml）引起的收缩活动被筒箭毒碱（d - Tc，10⁻⁵ g/ml）和美加明（Meca，10⁻⁵ g/ml）显著且可逆地抑制，被阿托品（Atr，10⁻⁴ g/ml）和六甲铵（C6，10⁻⁴ g/ml）轻微抑制。在豚鼠离体回肠标本中，乙酰胆碱（10⁻⁶ g/ml）引起的收缩活动被阿托品（10⁻⁶ g/ml）显著且可逆地抑制，而DMPP（10⁻⁶ g/ml）引起的活动被美加明（10⁻⁶ g/ml）、六甲铵（10⁻⁶ g/ml）和阿托品（10⁻⁶ g/ml）类似地抑制。虽然青蛙离体腹直肌标本可被4 - （间氯苯基氨甲酰氧基） - 2 - 丁炔基三甲基铵（McN - A - 343，10⁻⁵ g/ml）收缩，但不被毛果芸香碱（10⁻⁴ g/ml）收缩，蛔虫肌肉标本不受这些激动剂影响。青蛙离体腹直肌标本可被5 - 羟色胺（5 - HT，10⁻⁴ g/ml）收缩，但不受组胺（His，10⁻³ g/ml）和γ - 氨基丁酸（GABA，10⁻⁴ g/ml）影响，而蛔虫肌肉可被组胺（10⁻³ g/ml）收缩，被5 - HT（10⁻⁴ g/ml）和GABA（10⁻⁵ g/ml）舒张。这些结果表明，蛔虫肌肉和骨骼肌一样具有烟碱受体，且蛔虫肌肉具有与骨骼肌特异性不同的特性。
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