豚鼠去神经提睾肌作为一种药理制剂
The denervated cremaster muscle of the guinea-pig as a pharmacological preparation.
作者信息
Dale M M, Evinç A, Vine P
出版信息
Br J Pharmacol. 1976 Oct;58(2):229-37.
The pharmacological responses of both denervated and innervated cremaster muscle preparations from the guinea-pig have been investigated and compared. Acetylcholine (ACh) dose-response curves were obtained in both preparations. The affinity constants for (+)-tubocurarine and for atropine were calculated and indicated that the ACh receptors in both preparations were nicotinic. Histamine dose-response curves could be obtained only in the denervated preparation. The response was unaltered by metiamide, and the affinity constant for mepyramine fitted in with those previously obtained by others on ileum and trachea, indicating that the histamine receptors are H1 in type. Sustained contractions were obtained to adrenaline and noradrenaline but not isoprenaline, with the denervated preparations. Schultz-Dale responses were obtained with denervated muscle in sensitized guinea-pigs. This preparation did not respond to 5-hydroxytryptamine, bradykinin, or the slow-reacting substance of anaphylaxis.
对豚鼠去神经和有神经支配的提睾肌制剂的药理反应进行了研究和比较。在两种制剂中均获得了乙酰胆碱（ACh）剂量反应曲线。计算了（+）-筒箭毒碱和阿托品的亲和常数，表明两种制剂中的ACh受体均为烟碱样。组胺剂量反应曲线仅能在去神经制剂中获得。该反应不受甲硫咪特的影响，且美吡拉敏的亲和常数与其他人先前在回肠和气管上获得的常数相符，表明组胺受体为H1型。去神经制剂对肾上腺素和去甲肾上腺素产生持续收缩，但对异丙肾上腺素无反应。在致敏豚鼠中，去神经肌肉出现了舒尔茨-戴尔反应。该制剂对5-羟色胺、缓激肽或过敏反应慢反应物质无反应。
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