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The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts.

作者信息

Nambudiri A M, Ranganathan S, Rudney H

出版信息

J Biol Chem. 1980 Jun 25;255(12):5894-9.

PMID:7380842
Abstract
摘要

相似文献

1
The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts.3-羟基-3-甲基戊二酰辅酶A还原酶活性在人成纤维细胞中泛醌合成调节中的作用
J Biol Chem. 1980 Jun 25;255(12):5894-9.
2
The regulation of ubiquinone synthesis in fibroblasts: the effect of modulators of beta-hydroxy-beta-methylglutaryl-coenzyme A reductase activity.成纤维细胞中泛醌合成的调节：β-羟基-β-甲基戊二酰辅酶A还原酶活性调节剂的作用。
Arch Biochem Biophys. 1981 Sep;210(2):592-7. doi: 10.1016/0003-9861(81)90225-3.
3
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的可逆磷酸化调节：低密度脂蛋白、固醇和甲羟戊酸内酯对酶活性的调节
Arch Biochem Biophys. 1986 Jan;244(1):310-22. doi: 10.1016/0003-9861(86)90120-7.
4
Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway.
Arch Biochem Biophys. 1979 Jan;192(1):86-99. doi: 10.1016/0003-9861(79)90074-2.
5
Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.在培养的人成纤维细胞中由甲羟戊酸合成δ2-异戊烯基tRNA
J Biol Chem. 1980 Jul 25;255(14):6546-8.
6
Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein.
J Lipid Res. 1987 Oct;28(10):1199-205.
7
Regulation of cholesterol biosynthesis at a stage after the 3-hydroxy-3-methylglutaryl-CoA reductase step, in normal and leukemic (L2C) guinea pig lymphocytes.在正常和白血病（L2C）豚鼠淋巴细胞中，在3-羟基-3-甲基戊二酰辅酶A还原酶步骤之后的一个阶段对胆固醇生物合成的调节。
Biochim Biophys Acta. 1987 Sep 25;921(2):405-10. doi: 10.1016/0005-2760(87)90043-9.
8
Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.人成纤维细胞中的角鲨烯合酶活性：通过低密度脂蛋白受体进行调节。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5018-22. doi: 10.1073/pnas.76.10.5018.
9
Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2.洛伐他汀、甲羟戊酸和低密度脂蛋白对人肝癌细胞系Hep G2中3-羟基-3-甲基戊二酰辅酶A还原酶活性及低密度脂蛋白受体活性的影响
Biochem J. 1984 Aug 15;222(1):35-9. doi: 10.1042/bj2220035.
10
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells.3-羟基-3-甲基戊二酰辅酶A还原酶的活性对培养细胞中泛醌的摄取无反应。
Biochem J. 1987 Sep 1;246(2):441-7. doi: 10.1042/bj2460441.

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1
Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.他汀类药物诱导的肌肉损伤和肌萎缩相关基因1（atrogin-1）的诱导是香叶基香叶基化缺陷的结果。
FASEB J. 2009 Sep;23(9):2844-54. doi: 10.1096/fj.08-128843. Epub 2009 Apr 30.
2
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.肌肉特异性泛素连接酶atrogin-1/MAFbx介导他汀类药物诱导的肌肉毒性。
J Clin Invest. 2007 Dec;117(12):3940-51. doi: 10.1172/JCI32741.
3
Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2).
普伐他汀和d-柠檬烯对人肝癌细胞系（Hep G2）中甲羟戊酸途径及细胞生长的调节作用
Br J Cancer. 1994 Jun;69(6):1015-20. doi: 10.1038/bjc.1994.199.
4
Production and characterization of monoclonal antibodies to rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase.大鼠肝脏微粒体3-羟基-3-甲基戊二酰辅酶A还原酶单克隆抗体的制备与鉴定
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3734-8. doi: 10.1073/pnas.79.12.3734.
5
Overproduction of a Mr 92,000 protomer of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in compactin-resistant C100 cells.在对美伐他汀耐药的C100细胞中，3-羟基-3-甲基戊二酰辅酶A还原酶的一种分子量为92,000的亚基过度产生。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1516-20. doi: 10.1073/pnas.80.6.1516.
6
The effect of cholesterol on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis.胆固醇对梨形四膜虫中泛醌和四膜虫醇生物合成的影响。
Biochem J. 1983 Oct 15;216(1):203-6. doi: 10.1042/bj2160203.
7
Action of low-density lipoprotein and compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, on the synthesis of dolichol-linked oligosaccharides and low-density-lipoprotein receptor in human skin fibroblasts.低密度脂蛋白及美伐他汀（3-羟基-3-甲基戊二酰辅酶A还原酶的竞争性抑制剂）对人皮肤成纤维细胞中多萜醇连接的寡糖及低密度脂蛋白受体合成的作用。
Biochem J. 1981 May 15;196(2):625-8. doi: 10.1042/bj1960625.
8
Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.洛伐他汀（一种3-羟基-3-甲基戊二酰辅酶A还原酶的竞争性抑制剂）对小鼠神经母细胞瘤体内生长的抑制作用
J Clin Invest. 1985 Nov;76(5):1748-54. doi: 10.1172/JCI112165.
9
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells.3-羟基-3-甲基戊二酰辅酶A还原酶的活性对培养细胞中泛醌的摄取无反应。
Biochem J. 1987 Sep 1;246(2):441-7. doi: 10.1042/bj2460441.
10
Dolichol biosynthesis in human malignant cells.人类恶性细胞中的多萜醇生物合成
Biochem J. 1991 Sep 15;278 ( Pt 3)(Pt 3):741-7. doi: 10.1042/bj2780741.