Lust G, Beilman W T, Dueland D J, Farrell P W
J Bone Joint Surg Am. 1980;62(4):576-82.
The nature of the instability of the hip joint in dogs with dysplasia of the hip was investigated. In the experimental canine model, instability of the joint, as shown by subluxation of the femoral head on a roentgenogram, was accompanied by an increase in the volume of the synovial fluid and of the ligamentum teres and, therefore, an increase in the intra-articular volume. Injection of a buffered solution of hyaluronic acid into non-subluxated hip joints in situ increased subluxation, whereas withdrawal of synovial fluid from one joint with severe subluxation reduced the degree of subluxation. The withdrawal of varying amounts of synovial fluid from excised but intact joints resulted in a decrease in the lateral displacement of the femoral heads. Injection of the hyaluronic acid solution into excised joints resulted in increased lateral displacement of the femoral heads. The results suggest that the joint instability associated with canine hip dysplasia is related to increased intra-articular volume.
Instability of the hip joint (abnormal laxity) is a feature of hip dysplasia in dogs and congenital dislocation of the hip in children. The canine disease can provide a valuable model in which to examine the pathogenesis of hip instability. The model may be useful to test prophylactic procedures to prevent joint instability and thus ameliorate disease.
研究了髋关节发育不良犬髋关节不稳定的性质。在实验犬模型中，X线片显示股骨头半脱位所表明的关节不稳定，伴有滑液和圆韧带体积增加，因此关节内体积增加。向原位未半脱位的髋关节注射透明质酸缓冲溶液会增加半脱位，而从一个严重半脱位的关节抽取滑液会降低半脱位程度。从切除但完整的关节抽取不同量的滑液会导致股骨头外侧移位减少。向切除的关节注射透明质酸溶液会导致股骨头外侧移位增加。结果表明，与犬髋关节发育不良相关的关节不稳定与关节内体积增加有关。
髋关节不稳定（异常松弛）是犬髋关节发育不良和儿童先天性髋关节脱位的一个特征。犬类疾病可以提供一个有价值的模型来研究髋关节不稳定的发病机制。该模型可能有助于测试预防关节不稳定从而改善疾病的预防措施。
