Bloch W N, Karcioglu Z, Felner J M, Miller J S, Symbas P N, Schlant R C
Chest. 1978 Nov;74(5):579-81. doi: 10.1378/chest.74.5.579.
The report of a failure of glutaraldehyde-preserved porcine aortic xenograft bioprosthesis in the aortic position after 13 months is presented. Severe aortic regurgitation resulted from three "idiopathic" perforations in one of the cusps, and a linear tear in another cusp. Light and electron microscopy showed generalized degeneration of collagen thoughout the faulty valve. The absence of a platelet-fibrin coat on edges of the tear suggested a recent origin, compatible with cardiac catheter manipulation during unsuccessful attempts to cross the valve. The histopathologic data from this valve correlate with previously reported failures with formaldehyde preserved xenograft valves.
本文报告了一例戊二醛保存的猪主动脉异种移植生物假体在主动脉位置植入13个月后失败的病例。严重的主动脉瓣反流是由一个瓣叶上的三个“特发性”穿孔和另一个瓣叶上的一条线性撕裂所致。光镜和电镜检查显示，整个故障瓣膜的胶原普遍退变。撕裂边缘无血小板-纤维蛋白覆盖层，提示为近期形成，这与在试图穿过瓣膜未成功时进行的心导管操作相符。该瓣膜的组织病理学数据与先前报道的甲醛保存的异种移植瓣膜失败情况相关。
