Krogstad D J, Moellering R C, Greenblatt D J
J Clin Pharmacol. 1980 Apr;20(4):197-201. doi: 10.1002/j.1552-4604.1980.tb01696.x.
The pharmacokinetic properties of intravenously administered vancomycin were studied in four healthy volunteers. Reversible adverse effects (flushing, tachycardia, pruritus) occurred in two subjects who received high-dose rapid intravenous infusions. Distribution of vancomycin proceeded as a biphasic process in all four subjects. The initial distribution half-life (t1/2 alpha) was less than 8 minutes in all cases, with intermediate half-lives (t1/2 pi) varying from 0.43 to 1.48 hour and elimination half-lives (t1/2 beta) varying from 4.7 to 11.2 hours. Vancomycin clearance was less than creatinine clearance, probably because of serum protein binding, which was determined to be 55 per cent.
在四名健康志愿者身上研究了静脉注射万古霉素的药代动力学特性。两名接受高剂量快速静脉输注的受试者出现了可逆性不良反应（脸红、心动过速、瘙痒）。在所有四名受试者中，万古霉素的分布呈双相过程。所有病例的初始分布半衰期（t1/2α）均小于8分钟，中间半衰期（t1/2π）在0.43至1.48小时之间变化，消除半衰期（t1/2β）在4.7至11.2小时之间变化。万古霉素清除率低于肌酐清除率，这可能是由于血清蛋白结合率为55%所致。
