Young S N, Lal S
J Neural Transm. 1980;47(3):153-61. doi: 10.1007/BF01250597.
Lumbar CSF indoleacetic acid (IAA) was higher in patients with cirrhosis of the liver than in controls. It was also higher in CSF of patients in coma than in those with hepatic cirrhosis but not in coma. There was a strong correlation (r = 0.89, p less than 0.01) between the grade of hepatic coma and CSF IAA. These data indicate that there is an association between elevated CNS tryptamine metabolism and hepatic coma. How far changes in the metabolism of tryptamine and other trace amines are relevant to the induction of hepatic coma or are simply a reflection of advanced liver dysfunction is unclear.
肝硬化患者的腰椎脑脊液中吲哚乙酸（IAA）含量高于对照组。昏迷患者脑脊液中的IAA含量也高于肝硬化但未昏迷的患者。肝昏迷分级与脑脊液IAA之间存在强相关性（r = 0.89，p < 0.01）。这些数据表明中枢神经系统色胺代谢升高与肝昏迷之间存在关联。色胺和其他微量胺的代谢变化在多大程度上与肝昏迷的诱发有关，或者仅仅是晚期肝功能障碍的反映，目前尚不清楚。
