肝性脑病中的多巴胺和血清素代谢
Dopamine and serotonin metabolism in hepatic encephalopathy.
作者信息
Knell A J, Davidson A R, Williams R, Kantamaneni B D, Curzon G
出版信息
Br Med J. 1974 Mar 23;1(5907):549-51. doi: 10.1136/bmj.1.5907.549.
Abstract
Patients with stupor or coma from fulminant hepatic failure were found to have high cerebrospinal fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA), metabolites of dopamine and serotonin respectively. Excessive amounts of their precursors-phenylalanine and tyrosine and free tryptophan-were found in the patients' plasma. Methionine, which participates in dopamine degradation, was also much increased. Similar disturbances were found in patients suffering an acute exacerbation of chronic encephalopathy. These abnormalities would be consistent with other evidence of an increased turnover of serotonin and possibly dopamine in the brain during hepatic encephalopathy.
摘要
暴发性肝衰竭导致木僵或昏迷的患者，其脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度较高，它们分别是多巴胺和血清素的代谢产物。在这些患者的血浆中发现其前体物质——苯丙氨酸、酪氨酸和游离色氨酸的含量过高。参与多巴胺降解的蛋氨酸含量也大幅增加。在慢性脑病急性加重的患者中也发现了类似的紊乱情况。这些异常情况与肝性脑病期间大脑中血清素以及可能还有多巴胺周转率增加的其他证据相符。
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9
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本文引用的文献
1
Observations on the symptomatology and pathogenesis of hepatic coma.
Q J Med. 1951 Oct;20(80):421-38.
2
The neuropsychiatric syndrome associated with hepatic cirrhosis and an extensive portal collateral circulation.
Q J Med. 1956 Apr;25(98):245-66.
3
Studies on the free amino acids and related compounds in the tissues of the cat.
J Biol Chem. 1954 Dec;211(2):927-39.
4
Colorimetric micro-determination of free fatty acids in plasma.
Clin Chim Acta. 1967 Apr;16(1):57-62. doi: 10.1016/0009-8981(67)90269-0.
5
Treatment of hepatic coma by exchange blood transfusion.
N Engl J Med. 1966 Mar 3;274(9):473-81. doi: 10.1056/NEJM196603032740901.
6
Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with L-dopa.
J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):851-7. doi: 10.1136/jnnp.33.6.851.
7
Accelerated amino acid analysis: studies on the use of lithium citrate buffers and the effect of n-propanol, in the analysis of physiological fluids and protein hydrolyzates.
Anal Biochem. 1970 Dec;38(2):313-29. doi: 10.1016/0003-2697(70)90456-2.
8
Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man.
J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):269-72. doi: 10.1136/jnnp.33.2.269.
9
Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluid.
Clin Chim Acta. 1969 Nov;26(2):301-6. doi: 10.1016/0009-8981(69)90383-0.
10
Interaction in the cerebral metabolism of the biogenic amines: effect of intravenous infusion of L-tryptophan on the metabolism of dopamine and 5-hydroxyindoles in brain and cerebrospinal fluid.
Br J Pharmacol. 1971 Dec;43(4):715-23. doi: 10.1111/j.1476-5381.1971.tb07206.x.
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