肝性脑病中的多巴胺和血清素代谢
Dopamine and serotonin metabolism in hepatic encephalopathy.
作者信息
Knell A J, Davidson A R, Williams R, Kantamaneni B D, Curzon G
出版信息
Br Med J. 1974 Mar 23;1(5907):549-51. doi: 10.1136/bmj.1.5907.549.
Abstract
Patients with stupor or coma from fulminant hepatic failure were found to have high cerebrospinal fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA), metabolites of dopamine and serotonin respectively. Excessive amounts of their precursors-phenylalanine and tyrosine and free tryptophan-were found in the patients' plasma. Methionine, which participates in dopamine degradation, was also much increased. Similar disturbances were found in patients suffering an acute exacerbation of chronic encephalopathy. These abnormalities would be consistent with other evidence of an increased turnover of serotonin and possibly dopamine in the brain during hepatic encephalopathy.
摘要
暴发性肝衰竭导致木僵或昏迷的患者，其脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度较高，它们分别是多巴胺和血清素的代谢产物。在这些患者的血浆中发现其前体物质——苯丙氨酸、酪氨酸和游离色氨酸的含量过高。参与多巴胺降解的蛋氨酸含量也大幅增加。在慢性脑病急性加重的患者中也发现了类似的紊乱情况。这些异常情况与肝性脑病期间大脑中血清素以及可能还有多巴胺周转率增加的其他证据相符。
相似文献
1
Dopamine and serotonin metabolism in hepatic encephalopathy.肝性脑病中的多巴胺和血清素代谢
Br Med J. 1974 Mar 23;1(5907):549-51. doi: 10.1136/bmj.1.5907.549.
2
Brain transmitter precursors and metabolites in diabetic ketoacidosis.糖尿病酮症酸中毒中的脑递质前体和代谢产物。
J Neurol Neurosurg Psychiatry. 1982 Jun;45(6):489-93. doi: 10.1136/jnnp.45.6.489.
3
Monoamine precursors, transmitters and metabolites in cerebrospinal fluid: a prospective study in healthy male subjects.脑脊液中的单胺前体、递质和代谢产物：一项针对健康男性受试者的前瞻性研究。
J Psychiatr Res. 1996 May-Jun;30(3):201-8. doi: 10.1016/0022-3956(96)00007-6.
4
Continuous covariability of dopamine and serotonin metabolites in human cerebrospinal fluid.人脑脊液中多巴胺和血清素代谢物的连续协变性。
Biol Psychiatry. 1998 Aug 1;44(3):228-33. doi: 10.1016/s0006-3223(97)90372-3.
5
Cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, lactic acid, and pH before and after probenecid in hepatic coma.肝昏迷患者服用丙磺舒前后脑脊液中高香草酸、5-羟吲哚乙酸、乳酸及pH值的变化
Clin Neurol Neurosurg. 1975 Dec;77(2):142-52. doi: 10.1016/s0303-8467(74)80006-5.
6
Cerebral transmitter precursors and metabolites in advanced renal disease.晚期肾病中的脑递质前体和代谢产物
J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):581-8. doi: 10.1136/jnnp.41.7.581.
7
8
A longitudinal study of tryptophan involvement in hepatic coma.
Am J Surg. 1979 Feb;137(2):235-9. doi: 10.1016/0002-9610(79)90153-3.
9
Analysis of neurotransmitter metabolite concentrations in canine cerebrospinal fluid.犬脑脊液中神经递质代谢物浓度的分析。
Am J Vet Res. 1988 Aug;49(8):1302-6.
10
[Central metabolism of dopamine and serotonin. IV. Preliminary determinations of cerebrospinal fluid HVA and 5-HIAA in epileptic syndromes].[多巴胺与血清素的中枢代谢。IV. 癫痫综合征中脑脊液高香草酸和5-羟吲哚乙酸的初步测定]
Acta Neurol (Napoli). 1976 Sep-Oct;31(5):628-31.
引用本文的文献
1
Prediagnostic plasma metabolite concentrations and liver cancer risk: A nested case-control study with long follow-up in the Shanghai Women's Health Study.诊断前血浆代谢物浓度与肝癌风险：上海女性健康研究中的一项长期随访巢式病例对照研究。
Int J Cancer. 2025 Jun 23. doi: 10.1002/ijc.70004.
2
Haloperidol dopamine receptor occupancy and antagonism correspond to delirium agitation scores and EPS risk: A PBPK-PD modeling analysis.氟哌啶醇对多巴胺受体的占有率和拮抗作用与谵妄躁动评分及锥体外系反应风险的关系：一项基于生理药代动力学-药效学（PBPK-PD）模型的分析
J Psychopharmacol. 2025 Mar;39(3):244-253. doi: 10.1177/02698811241309620. Epub 2025 Jan 4.
3
A Retrospective Analysis of Guanfacine for the Pharmacological Management of Delirium.胍法辛用于谵妄药物治疗的回顾性分析
Cureus. 2023 Jan 5;15(1):e33393. doi: 10.7759/cureus.33393. eCollection 2023 Jan.
4
The critical role of hippocampal dopamine in the pathogenesis of hepatic encephalopathy.海马多巴胺在肝性脑病发病机制中的关键作用。
Physiol Res. 2021 Mar 17;70(1):101-110. doi: 10.33549/physiolres.934563. Epub 2021 Jan 14.
5
MetaboRank: network-based recommendation system to interpret and enrich metabolomics results.MetaboRank：一种基于网络的推荐系统，用于解释和丰富代谢组学结果。
Bioinformatics. 2019 Jan 15;35(2):274-283. doi: 10.1093/bioinformatics/bty577.
6
Dopamine Burden Triggers Neurodegeneration via Production and Release of TNF-α from Astrocytes in Minimal Hepatic Encephalopathy.多巴胺负担通过星形胶质细胞产生和释放 TNF-α引发轻微型肝性脑病的神经退行性变。
Mol Neurobiol. 2016 Oct;53(8):5324-43. doi: 10.1007/s12035-015-9445-2. Epub 2015 Oct 3.
7
A computational approach to estimate interorgan metabolic transport in a mammal.一种估算哺乳动物体内器官间代谢物转运的计算方法。
PLoS One. 2014 Jun 27;9(6):e100963. doi: 10.1371/journal.pone.0100963. eCollection 2014.
8
[Delirium in the intensive care unit].[重症监护病房中的谵妄]
Anaesthesist. 2010 Mar;59(3):235-47. doi: 10.1007/s00101-009-1664-3.
9
Serotonin brain circuits with a focus on hepatic encephalopathy.以肝性脑病为重点的血清素脑回路。
Metab Brain Dis. 2004 Dec;19(3-4):413-20. doi: 10.1023/b:mebr.0000043985.25055.b3.
10
Effect of probenecid on 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid of rats with portacaval anastomosis.丙磺舒对门腔静脉吻合大鼠脑池脑脊液中5-羟吲哚乙酸的影响。
Neurochem Res. 1995 Aug;20(8):963-7. doi: 10.1007/BF00970743.
本文引用的文献
1
Observations on the symptomatology and pathogenesis of hepatic coma.关于肝昏迷症状学及发病机制的观察
Q J Med. 1951 Oct;20(80):421-38.
2
3
Studies on the free amino acids and related compounds in the tissues of the cat.猫组织中游离氨基酸及相关化合物的研究。
J Biol Chem. 1954 Dec;211(2):927-39.
4
Colorimetric micro-determination of free fatty acids in plasma.血浆中游离脂肪酸的比色微量测定法。
Clin Chim Acta. 1967 Apr;16(1):57-62. doi: 10.1016/0009-8981(67)90269-0.
5
Treatment of hepatic coma by exchange blood transfusion.换血疗法治疗肝昏迷。
N Engl J Med. 1966 Mar 3;274(9):473-81. doi: 10.1056/NEJM196603032740901.
6
Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with L-dopa.接受左旋多巴治疗的帕金森病患者腰椎脑脊液中的酚酸浓度。
J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):851-7. doi: 10.1136/jnnp.33.6.851.
7
Accelerated amino acid analysis: studies on the use of lithium citrate buffers and the effect of n-propanol, in the analysis of physiological fluids and protein hydrolyzates.加速氨基酸分析：关于在生理体液和蛋白质水解产物分析中使用柠檬酸锂缓冲液及正丙醇影响的研究。
Anal Biochem. 1970 Dec;38(2):313-29. doi: 10.1016/0003-2697(70)90456-2.
8
Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man.色氨酸给药对人体脑脊液中5-羟吲哚乙酸的影响。
J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):269-72. doi: 10.1136/jnnp.33.2.269.
9
Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluid.荧光法测定人尿液和脑脊液中的5-羟吲哚乙酸
Clin Chim Acta. 1969 Nov;26(2):301-6. doi: 10.1016/0009-8981(69)90383-0.
10
Interaction in the cerebral metabolism of the biogenic amines: effect of intravenous infusion of L-tryptophan on the metabolism of dopamine and 5-hydroxyindoles in brain and cerebrospinal fluid.生物胺脑代谢中的相互作用：静脉输注L-色氨酸对脑和脑脊液中多巴胺及5-羟吲哚代谢的影响。
Br J Pharmacol. 1971 Dec;43(4):715-23. doi: 10.1111/j.1476-5381.1971.tb07206.x.
Zotero 插件