Slattery J T
J Pharmacokinet Biopharm. 1980 Feb;8(1):105-10. doi: 10.1007/BF01059452.
A maintenance dose designed to give a desired minimum concentration of drug in plasma at steady-state can be determined in a model-independent manner assuming that concentration-time data needed for the calculation are obtained after absorption and distribution are complete. Using a few concentration-time points obtained after the first dose, numerical values of beta and Z a parameter consisting of different pharmacokinetic parameters for different models, can be obtained. An administration interval (tau) can be chosen based on beta. Using the values of beta, Z, and tau, a maintenance dose is calculated. This approach will allow calculation of a maintenance dose when drug is present in plasma at the time the first monitored dose is given.
在假设计算所需的浓度-时间数据是在吸收和分布完成后获得的情况下，可以以与模型无关的方式确定维持剂量，该维持剂量旨在在稳态时使血浆中药物达到所需的最低浓度。使用首剂给药后获得的几个浓度-时间点，可以得到β和Z（Z是由不同模型的不同药代动力学参数组成的一个参数）的数值。可以根据β选择给药间隔（τ）。利用β、Z和τ的值计算维持剂量。当给予首次监测剂量时血浆中已有药物存在时，这种方法将能够计算维持剂量。
