Edel B, Baltzer M O
J Pharm Sci. 1980 Mar;69(3):287-90. doi: 10.1002/jps.2600690311.
Data required for predicting the stability of an active principle in solution can be obtained by two kinetic methods. With the isothermal method, the degradation rate constants are determined at different temperatures, which are kept constant throughout the experiment. With the nonisothermal method, the temperature is increased with time. This paper describes a nonisothermal kinetic method in which the temperature is increased in consecutive equal steps. The results are compared with those obtained by the conventional isothermal method. The values for the activation energy are approximately the same by both methods. Although the technique of nonisothermal kinetics demands sophisticated equipment and high experimental accuracy, it provides a continuous picture over a wide temperature range.
预测溶液中活性成分稳定性所需的数据可通过两种动力学方法获得。采用等温法时，在不同温度下测定降解速率常数，且在整个实验过程中温度保持恒定。采用非等温法时，温度随时间升高。本文描述了一种非等温动力学方法，其中温度以连续相等的步长升高。将结果与传统等温法获得的结果进行比较。两种方法得到的活化能值大致相同。尽管非等温动力学技术需要精密的设备和较高的实验精度，但它能在很宽的温度范围内提供连续的情况。
